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1/10/2023 12:57:44 PM | Browse: 190 | Download: 608
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Received |
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2022-09-20 16:03 |
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Peer-Review Started |
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2022-09-20 16:06 |
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To Make the First Decision |
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Return for Revision |
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2022-10-14 22:14 |
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Revised |
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2022-10-28 21:52 |
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Second Decision |
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2022-12-07 03:23 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-12-07 18:03 |
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Articles in Press |
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2022-12-07 18:03 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-12-13 04:19 |
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Publish the Manuscript Online |
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2023-01-10 08:49 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Challenges and exploration for immunotherapies targeting cold colorectal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Dan-Dan Li, Yuan-Ling Tang and Xin Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82073338 |
| Sichuan Science and Technology Support Project |
No. 2021YFSY0039，No. 22ZDYF0499 |
| The 1·3·5 Project for Disciplines of Excellence–Clinical Research Incubation Project West China Hospital, Sichuan University |
No. 2020HXFH002 |
| The 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University |
No. ZYJC21059 |
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| Corresponding Author |
Xin Wang, MD, PhD, Professor, Department of Abdominal Oncology/Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, No. 37 Wainan Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan Province, China. wangxin213@sina.com |
| Key Words |
Colorectal cancer; Immune checkpoint inhibitors; Cold tumors; Immunotherapy mechanism; Combination therapy; Effector T cells |
| Core Tip |
This review focuses on the potential mechanism of immunotherapy ineffectiveness in colorectal cancer patients with “cold tumors”, how to increase the infiltration of effector T cells at tumor sites by combination therapy strategies, how to transform “cold tumors” into “hot tumors” to expand the number of people benefiting from immunotherapy, and make recommendations on how to screen out immune-dominant populations in the future. |
| Publish Date |
2023-01-10 08:49 |
| Citation |
Li DD, Tang YL, Wang X. Challenges and exploration for immunotherapies targeting cold colorectal cancer. World J Gastrointest Oncol 2023; 15(1): 55-68 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i1/55.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i1.55 |
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