Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	80285
Country	China

Received	2022-09-28 10:49
Peer-Review Started	2022-09-28 10:49
To Make the First Decision
Return for Revision	2022-10-21 08:43
Revised	2022-11-01 14:24
Second Decision	2022-12-20 08:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-12-21 07:31
Articles in Press	2022-12-21 07:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-01-03 06:23
Publish the Manuscript Online	2023-01-10 08:49

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Basic Study
Article Title	Hsa_circ_0001658 accelerates the progression of colorectal cancer through miR-590-5p/METTL3 regulatory axis
Manuscript Source	Unsolicited Manuscript
All Author List	Yang Lu, Xing-Ming Wang, Ze-Shu Li, Ai-Juan Wu and Wen-Xia Cheng
Funding Agency and Grant Number
Corresponding Author	Yang Lu, MMed, Chief Physician, Department of Oncology, PKUCare Luzhong Hospital, No. 65, Taigong Road, Linzi District, Zibo 255400, Shandong Province, China. ly76730@163.com
Key Words	Circ_0001658; miR-590-5p; METTL3; Colorectal cancer; Proliferation
Core Tip	As we know, the progression of colorectal cancer (CRC) is significantly influenced by circular RNAs (circRNAs). This study focused on circRNA_0001658 (circ_0001658) and delved into how it works in CRC. The results confirmed that circ_0001658 and methyltransferase-like 3 (METTL3) mRNA expression in CRC tissues and cells were increased, while miR-590-5p was decreased. Circ_0001658 was inversely associated with miR-590-5p expression while positively with METTL3 expressions. In a word, circ_0001658 accelerates the progression of CRC through miR-590-5p/METTL3 regulatory axis.
Publish Date	2023-01-10 08:49
Citation	Lu Y, Wang XM, Li ZS, Wu AJ, Cheng WX. Hsa_circ_0001658 accelerates the progression of colorectal cancer through miR-590-5p/METTL3 regulatory axis. World J Gastrointest Oncol 2023;15(1): 76-89
URL	https://www.wjgnet.com/1948-5204/full/v15/i1/76.htm
DOI	https://dx.doi.org/10.4251/wjgo.v15.i1.76

Full Article (PDF)	WJGO-15-76.pdf
Full Article (Word)	WJGO-15-76.docx
Manuscript File	80285_Auto_Edited-JLW.docx
Answering Reviewers	80285-Answering reviewers.pdf
Audio Core Tip	80285-Audio core tip.m4a
Biostatistics Review Certificate	80285-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	80285-Conflict-of-interest statement.pdf
Copyright License Agreement	80285-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	80285-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	80285-Language certificate.pdf
Supplementary Material	80285-Informed consent statement.pdf
Peer-review Report	80285-Peer-review(s).pdf
Scientific Misconduct Check	80285-Bing-Liu GL-2.png
Scientific Editor Work List	80285-Scientific editor work list.pdf
CrossCheck Report	80285-CrossCheck report.pdf