| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Dickkopf-related protein 1/cytoskeleton-associated protein 4 signaling activation by Helicobacter pylori-induced activator protein-1 promotes gastric tumorigenesis via the PI3K/AKT/mTOR pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Mei Luo, Yuan-Jia Chen, Yuan Xie, Qin-Rong Wang, Yi-Ning Xiang, Ni-Ya Long, Wen-Xiu Yang, Yan Zhao and Jian-Jiang Zhou |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
32160166, 31760328, 31960028 |
| Natural Science Foundation of Guizhou Province |
ZC[2020]4Y026,JC[2020] 1Z010 |
| Natural Science Foundation of Guizhou Province |
JC[2020]1Y333,ZK[2022]041 |
| Scientific Research Project of Guizhou Medical University |
20NSP068 |
|
| Corresponding Author |
Jian-Jiang Zhou, Doctor, Professor, Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, No. 9 Beijing Road, Guiyang 550004, Guizhou Province, China. 851827202@qq.com |
| Key Words |
Gastric cancer; Helicobacter pylori; Dickkopf-related protein 1; Cytoskeleton-associated protein 4; Phosphatidylinositol 3-kinase pathway |
| Core Tip |
Helicobacter pylori (H. pylori) infection is the most significant risk factor for gastric cancer (GC). More than half of the global population has H. pylori infection, and 1%-3% of the infected individuals develop GC, but the mechanism behind this link remains unclear. Here, we identified 32 highly expressed genes in H. pylori-infected GC cells and demonstrated that H. pylori-induced high expression of JUN and fos-like antigen-1 formed activator protein-1 to transcriptionally activate dickkopf-related protein (DKK) 1, which by binding to cytoskeleton-associated protein 4 (CKAP4) receptor activated the PI3K/AKT/mammalian target of rapamycin pathway and, consequently, gastric tumorigenesis. Targeting the DKK1/CKAP4 interaction may be a novel strategy to treat GC. |
| Publish Date |
2022-12-19 10:48 |
| Citation |
Luo M, Chen YJ, Xie Y, Wang QR, Xiang YN, Long NY, Yang WX, Zhao Y, Zhou JJ. Dickkopf-related protein 1/cytoskeleton-associated protein 4 signaling activation by Helicobacter pylori-induced activator protein-1 promotes gastric tumorigenesis via the PI3K/AKT/mTOR pathway. World J Gastroenterol 2022; 28(47): 6769-6787 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i47/6769.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i47.6769 |
