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2/21/2023 6:42:14 AM | Browse: 215 | Download: 714
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Received |
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2022-09-28 10:22 |
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Peer-Review Started |
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2022-09-28 10:25 |
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To Make the First Decision |
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Return for Revision |
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2022-12-12 08:19 |
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Revised |
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2022-12-26 18:46 |
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Second Decision |
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2023-02-06 09:01 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-02-14 23:15 |
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Articles in Press |
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2023-02-14 23:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-02-15 07:31 |
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Publish the Manuscript Online |
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2023-02-21 06:19 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Nutrition & Dietetics |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Influence of methyl donor nutrients as epigenetic regulators in colorectal cancer: A systematic review of observational studies
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Lourdes Pilar Chávez-Hidalgo, Silvia Martín-Fdz-de-Labastida, Marian M de Pancorbo and Marta Arroyo-Izaga |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Basque Government (BIOMICs Research Group, MICROFLUIDICs & BIOMICs Cluster of the University of the Basque Country UPV/EHU) |
IT1633-22 |
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| Corresponding Author |
Marta Arroyo-Izaga, PharmD, N/A, N/A, Department of Pharmacy and Food Sciences, Faculty of Pharmacy, University of the Basque Country UPV/EHU, Paseo de la Universidad, No. 7, Vitoria-Gasteiz 01006, Araba/Álava, Spain. marta.arroyo@ehu.eus |
| Key Words |
Colorectal cancer; DNA methylation; Epigenetics; Methyl donors; Microsatellite instability; Nutrients |
| Core Tip |
Dietary methyl donors might influence DNA methylation during the carcinogenesis of colorectal cancer (CRC). However, whether the influence of methyl donor intake is modified by polymorphisms in such epigenetic regulators is still unclear. We conducted a systematic review on this topic to improve the current understanding of the molecular basis of CRC. Several studies have suggested interactions between methylenetetrahydrofolate reductase polymorphisms, donor methyl nutrients (such as folate) and alcohol on CRC risk. Moreover, vitamin B6, niacin, and alcohol may affect CRC risk through not only genetic but also epigenetic regulation. |
| Publish Date |
2023-02-21 06:19 |
| Citation |
Chávez-Hidalgo LP, Martín-Fernández-de-Labastida S, M de Pancorbo M, Arroyo-Izaga M. Influence of methyl donor nutrients as epigenetic regulators in colorectal cancer: A systematic review of observational studies. World J Gastroenterol 2023; 29(7): 1219-1234 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i7/1219.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i7.1219 |
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