Publication Name	World Journal of Gastroenterology
Manuscript ID	80478
Country	Australia

Received	2022-09-29 15:22
Peer-Review Started	2022-09-29 15:24
To Make the First Decision
Return for Revision	2023-01-03 21:06
Revised	2023-01-17 11:10
Second Decision	2023-02-10 03:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-02-22 00:46
Articles in Press	2023-02-22 00:46
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-03-01 04:25
Typeset the Manuscript	2023-03-07 08:32
Publish the Manuscript Online	2023-03-10 07:29

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Precision medicine in inflammatory bowel disease: Individualising the use of biologics and small molecule therapies
Manuscript Source	Invited Manuscript
All Author List	Eric Cheah and James Guoxian Huang
Funding Agency and Grant Number
Corresponding Author	James Guoxian Huang, MBBS, Assistant Professor, Attending Doctor, Staff Physician, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block Level 12, 1E Kent Ridge Road, Singapore 119228, Singapore. james_huang@nuhs.edu.sg
Key Words	Precision medicine; Therapeutic ceiling; Inflammatory bowel disease; Biologics; Small molecules
Core Tip	Precision medicine and individualising patient care has been the holy grail in the management of inflammatory bowel disease (IBD). A one-size-fits-all approach, utilising the current armamentarium of biologics and small molecules, still yields less than ideal clinical outcomes, with significantly high non-response rates. Multiple challenges remain in breaking this therapeutic ceiling: achieving an early diagnosis of IBD ideally even in the pre-clinical phase, accurately prognosticating the disease course and tailoring an appropriately sequenced therapy regime to a patient disease severity, pharmacokinetic and pharmacodynamic profile.
Publish Date	2023-03-10 07:29
Citation	Cheah E, Huang JG. Precision medicine in inflammatory bowel disease: Individualising the use of biologics and small molecule therapies. World J Gastroenterol 2023; 29(10): 1539-1550
URL	https://www.wjgnet.com/1007-9327/full/v29/i10/1539.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i10.1539

Full Article (PDF)	WJG-29-1539.pdf
Full Article (Word)	WJG-29-1539.docx
Manuscript File	80478-Review-FilipodiaCLv1.docx
Answering Reviewers	80478-Answering reviewers.pdf
Audio Core Tip	80478-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	80478-Conflict-of-interest statement.pdf
Copyright License Agreement	80478-Copyright license agreement.pdf
Peer-review Report	80478-Peer-review(s).pdf
Scientific Editor Work List	80478-Scientific editor work list.pdf