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3/21/2023 10:03:17 AM | Browse: 389 | Download: 1201
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Received |
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2022-10-12 20:22 |
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Peer-Review Started |
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2022-10-12 20:25 |
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First Decision by Editorial Office Director |
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2022-11-03 08:01 |
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Return for Revision |
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2022-11-03 15:45 |
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Revised |
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2022-11-08 09:44 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2023-01-16 03:46 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2023-01-16 20:25 |
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Articles in Press |
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2023-01-16 20:25 |
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Edit the Manuscript by Language Editor |
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2022-12-29 23:04 |
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Typeset the Manuscript |
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2023-03-17 03:00 |
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Publish the Manuscript Online |
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2023-03-21 09:36 |
| ISSN |
2220-3249 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Review |
| Article Title |
Intestinal barrier dysfunction as a key driver of severe COVID-19
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Efthymios P Tsounis, Christos Triantos, Christos Konstantakis, Markos Marangos and Stelios F Assimakopoulos |
| Funding Agency and Grant Number |
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| Corresponding Author |
Stelios F Assimakopoulos, MD, PhD, Associate Professor, Division of Infectious Diseases, Department of Internal Medicine, Medical School, University of Patras, University Hospital of Patras, Rion, Patras 26504, Greece. sassim@upatras.gr |
| Key Words |
COVID-19; SARS-CoV-2; Intestinal barrier; Dysbiosis; Immunothrombosis; Gut-lung axis |
| Core Tip |
Severe coronavirus disease 2019 (COVID-19) is associated with a multi-layered disruption of gut barrier integrity. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inflicts direct cytopathic or indirect immune-mediated injury to intestinal epithelial and endothelial cells and enhances paracellular permeability by downregulating tight junction proteins. SARS-CoV-2 induces profound gut microbiome alterations accompanied by dysregulation of mucosal immune responses. Gut dysbiosis attenuates, through the gut-lung axis, the ability of the respiratory immune system to elicit vigorous responses to contain SARS-CoV-2. Additionally, intestinal barrier dysfunction promotes endothelial activation and predisposes to detrimental COVID-19-related thrombotic complications. Finally, bacterial translocation and endotoxemia contribute to over-exuberant immune responses and hyper-inflammation in severe COVID-19. |
| Publish Date |
2023-03-21 09:36 |
| Citation |
Tsounis EP, Triantos C, Konstantakis C, Marangos M, Assimakopoulos SF. Intestinal barrier dysfunction as a key driver of severe COVID-19. World J Virol 2023; 12(2): 68-90 |
| URL |
https://www.wjgnet.com/2220-3249/full/v12/i2/68.htm |
| DOI |
https://dx.doi.org/10.5501/wjv.v12.i2.68 |
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