Publication Name	World Journal of Virology
Manuscript ID	80792
Country	Greece

Received	2022-10-12 20:22
Peer-Review Started	2022-10-12 20:25
To Make the First Decision
Return for Revision	2022-11-03 15:45
Revised	2022-11-08 09:44
Second Decision	2023-01-16 03:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-01-16 20:25
Articles in Press	2023-01-16 20:25
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-12-29 23:04
Typeset the Manuscript	2023-03-17 03:00
Publish the Manuscript Online	2023-03-21 09:36

ISSN	2220-3249 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Infectious Diseases
Manuscript Type	Review
Article Title	Intestinal barrier dysfunction as a key driver of severe COVID-19
Manuscript Source	Invited Manuscript
All Author List	Efthymios P Tsounis, Christos Triantos, Christos Konstantakis, Markos Marangos and Stelios F Assimakopoulos
Funding Agency and Grant Number
Corresponding Author	Stelios F Assimakopoulos, MD, PhD, Associate Professor, Division of Infectious Diseases, Department of Internal Medicine, Medical School, University of Patras, University Hospital of Patras, Rion, Patras 26504, Greece. sassim@upatras.gr
Key Words	COVID-19; SARS-CoV-2; Intestinal barrier; Dysbiosis; Immunothrombosis; Gut-lung axis
Core Tip	Severe coronavirus disease 2019 (COVID-19) is associated with a multi-layered disruption of gut barrier integrity. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inflicts direct cytopathic or indirect immune-mediated injury to intestinal epithelial and endothelial cells and enhances paracellular permeability by downregulating tight junction proteins. SARS-CoV-2 induces profound gut microbiome alterations accompanied by dysregulation of mucosal immune responses. Gut dysbiosis attenuates, through the gut-lung axis, the ability of the respiratory immune system to elicit vigorous responses to contain SARS-CoV-2. Additionally, intestinal barrier dysfunction promotes endothelial activation and predisposes to detrimental COVID-19-related thrombotic complications. Finally, bacterial translocation and endotoxemia contribute to over-exuberant immune responses and hyper-inflammation in severe COVID-19.
Publish Date	2023-03-21 09:36
Citation	Tsounis EP, Triantos C, Konstantakis C, Marangos M, Assimakopoulos SF. Intestinal barrier dysfunction as a key driver of severe COVID-19. World J Virol 2023; 12(2): 68-90
URL	https://www.wjgnet.com/2220-3249/full/v12/i2/68.htm
DOI	https://dx.doi.org/10.5501/wjv.v12.i2.68

Full Article (PDF)	WJV-12-68.pdf
Full Article (Word)	WJV-12-68.docx
Manuscript File	80792_Auto_edited-LM.docx
Answering Reviewers	80792-Answering reviewers.pdf
Audio Core Tip	80792-Audio core tip.aac
Conflict-of-Interest Disclosure Form	80792-Conflict-of-interest statement.pdf
Copyright License Agreement	80792-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	80792-Language certificate.pdf
Peer-review Report	80792-Peer-review(s).pdf
Scientific Misconduct Check	80792-Bing-Gao CC-2.png
Scientific Editor Work List	80792-Scientific editor work list.pdf
CrossCheck Report	80792-CrossCheck report.pdf