Publication Name	World Journal of Critical Care Medicine
Manuscript ID	80845
Country	Spain

Received	2022-10-14 09:18
Peer-Review Started	2022-10-14 09:20
To Make the First Decision
Return for Revision	2022-11-22 09:00
Revised	2022-12-09 16:49
Second Decision	2023-01-28 03:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-02-01 23:04
Articles in Press	2023-02-01 23:04
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-01-23 01:10
Typeset the Manuscript	2023-02-03 03:04
Publish the Manuscript Online	2023-03-07 03:37

ISSN	2220-3141(online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Clinical Neurology
Manuscript Type	Observational Study
Article Title	Elevated soluble fas blood concentrations in patients dying from spontaneous intracerebral hemorrhage
Manuscript Source	Invited Manuscript
All Author List	Leonardo Lorente, María M Martín, Antonia Pérez-Cejas, Luis Ramos-Gómez, Jordi Solé-Violan, Juan J Cáceres, Alejandro Jiménez and Agustín F González-Rivero
Funding Agency and Grant Number
Corresponding Author	Leonardo Lorente, MD, PhD, Attending Doctor, Medical Assistant, Department of Intensive Care, Hospital Universitario de Canarias, Ofra s/n, La Laguna 38320, Tenerife, Spain. lorentemartin@msn.com
Key Words	Spontaneous intracerebral hemorrhage; Soluble fas; Apoptosis; Patients; Mortality
Core Tip	Several studies of spontaneous intracerebral hemorrhage (SICH) patients have shown apoptotic changes in brain samples after hematoma evacuation. However, there are no data on the association of blood concentrations of soluble fas (sFas) (the main surface death receptor of the extrinsic apoptosis pathway) with SICH patient prognosis. The objective of our study was to determine whether there is an association between blood sFas concentrations and SICH patient mortality. The association of blood sFas concentrations with SICH patient mortality is a novel finding of this study.
Publish Date	2023-03-07 03:37
Citation	Lorente L, Martín MM, Pérez-Cejas A, Ramos-Gómez L, Solé-Violan J, Cáceres JJ, Jiménez A, González-Rivero AF. Elevated soluble fas blood concentrations in patients dying from spontaneous intracerebral hemorrhage. World J Crit Care Med 2023; 12(2): 63-70
URL	https://www.wjgnet.com/2220-3141/full/v12/i2/63.htm
DOI	https://dx.doi.org/10.5492/wjccm.v12.i2.63

Full Article (PDF)	WJCCM-12-63.pdf
Full Article (Word)	WJCCM-12-63.docx
Manuscript File	80845_Auto_Edited-LM.docx
Answering Reviewers	80845-Answering reviewers.pdf
Audio Core Tip	80845-Audio core tip.opus
Biostatistics Review Certificate	80845-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	80845-Conflict-of-interest statement.pdf
Copyright License Agreement	80845-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	80845-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	80845-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	80845-Language certificate.pdf
Peer-review Report	80845-Peer-review(s).pdf
Scientific Misconduct Check	80845-Bing-Wang LL-2.png
Scientific Editor Work List	80845-Scientific editor work list.pdf