Publication Name	World Journal of Gastroenterology
Manuscript ID	81153
Country	Lithuania

Received	2022-10-27 11:58
Peer-Review Started	2022-10-27 12:00
First Decision by Editorial Office Director	2022-11-14 08:44
Return for Revision	2022-11-14 08:44
Revised	2022-11-19 13:10
Publication Fee Transferred
Second Decision by Editor	2022-12-20 08:13
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2022-12-21 07:25
Articles in Press	2022-12-21 07:25
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-12-26 01:58
Publish the Manuscript Online	2023-02-21 06:19

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Comparison of genomic and transcriptional microbiome analysis in gastric cancer patients and healthy individuals
Manuscript Source	Unsolicited Manuscript
All Author List	Darja Nikitina, Konrad Lehr, Ramiro Vilchez-Vargas, Laimas Virginijus Jonaitis, Mindaugas Urba, Juozas Kupcinskas, Jurgita Skieceviciene and Alexander Link
Funding Agency and Grant Number	Funding Agency Grant Number European Social Fund 09.3.3-LMT-K-712-01 0130 “Autonomy in old Age” research group ZS/2018/11/95324
Corresponding Author	Jurgita Skieceviciene, PhD, Professor, Senior Researcher, Institute for Digestive Research, Lithuanian University of Health Sciences, Eivenių g. 4, Kaunas 44307, Lithuania. jurgita.skieceviciene@lsmu.lt
Key Words	Gastric cancer; Microbiome; Helicobacter pylori; 16S rRNA gene; 16S rRNA transcript; 16S rDNA
Core Tip	In this study, we aimed to characterize the microbiota of gastric cancer (GC) on two levels: 16S rRNA gene and its transcript. Our study showed that only a small portion of bacterial sequences overlapped using those two approaches. Moreover, our study revealed that obtained results comparing the case group with the controls depend on the chosen modality. We also showed that Reyranella and Sediminibacterium was associated with the Lauren classification and RNA level was more sensitive to detect low abundant bacteria. This study provides novel insights into microbiome study as well as new founding related to complex GC pathogenesis.
Publish Date	2023-02-21 06:19
Citation	Nikitina D, Lehr K, Vilchez-Vargas R, Jonaitis LV, Urba M, Kupcinskas J, Skieceviciene J, Link A. Comparison of genomic and transcriptional microbiome analysis in gastric cancer patients and healthy individuals. World J Gastroenterol 2022; 29(7): 1202-1218
URL	https://www.wjgnet.com/1007-9327/full/v29/i7/1202.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i7.1202

Full Article (PDF)	WJG-29-1202.pdf
Full Article (Word)	WJG-29-1202.docx