Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	81432
Country	United States

Received	2022-11-27 21:41
Peer-Review Started	2022-11-27 21:43
To Make the First Decision
Return for Revision	2022-12-13 10:42
Revised	2022-12-25 18:23
Second Decision	2023-01-09 04:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-01-10 22:57
Articles in Press	2023-01-10 22:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-03-01 08:32
Publish the Manuscript Online	2023-03-06 09:33

ISSN	2219-2808 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pediatrics
Manuscript Type	Opinion Review
Article Title	Higher rates of autism and attention deficit/hyperactivity disorder in American children: Are food quality issues impacting epigenetic inheritance?
Manuscript Source	Invited Manuscript
All Author List	Renee J Dufault, Raquel A Crider, Richard C Deth, Roseanne Schnoll, Steven G Gilbert, Walter J Lukiw and Amanda L Hitt
Funding Agency and Grant Number
Corresponding Author	Renee J Dufault, PhD, Doctor, Department of Research, Food Ingredient and Health Research Institute, PO Box 1055, Naalehu, HI 96772, United States. rdufault@foodingredient.info
Key Words	Lead exposure; Mercury; Oxidative stress; Methylation patterns; Epigenetic inheritance; Autism
Core Tip	Heavy metal residues are pervasive in the food supply and allowed by the Code of Federal Regulations because of food ingredient manufacturing processes. Children fed food with heavy metal residues may bioaccumulate inorganic mercury and lead in their blood and exhibit symptoms of autism or attention deficit/hyperactivity-disorder. Prenatal dietary exposures to heavy metals may impact gene activity in children and create learning difficulties requiring special education services. Educators see an increase in the prevalence of autism and developmental delay with cases doubling or tripling since 2006. Food quality issues may be impacting epigenetic inheritance of autism and related disorders.
Publish Date	2023-03-06 09:33
Citation	Dufault RJ, Crider RA, Deth RC, Schnoll R, Gilbert SG, Lukiw WJ, Hitt AL. Higher rates of autism and attention deficit/hyperactivity disorder in American children: Are food quality issues impacting epigenetic inheritance? World J Clin Pediatr 2023; 12(2): 25-37
URL	https://www.wjgnet.com/2219-2808/full/v12/i2/25.htm
DOI	https://dx.doi.org/10.5409/wjcp.v12.i2.25

Full Article (PDF)	WJCP-12-25.pdf
Full Article (Word)	WJCP-12-25.docx
Manuscript File	81432_Auto_Edited-LM.docx
Answering Reviewers	81432-Answering reviewers.pdf
Audio Core Tip	81432-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	81432-Conflict-of-interest statement.pdf
Copyright License Agreement	81432-Copyright license agreement.pdf
Supplementary Material	81432-Supplementary material.pdf
Peer-review Report	81432-Peer-review(s).pdf
Scientific Misconduct Check	81432-Bing-Wang JJ-2.png
Scientific Editor Work List	81432-Scientific editor work list.pdf