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2/15/2023 10:56:12 AM | Browse: 324 | Download: 888
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Received |
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2022-11-20 10:36 |
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Peer-Review Started |
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2022-11-20 10:36 |
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To Make the First Decision |
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Return for Revision |
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2022-12-14 13:56 |
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Revised |
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2022-12-21 13:15 |
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Second Decision |
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2022-12-30 03:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-12-31 05:35 |
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Articles in Press |
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2022-12-31 05:35 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-01-07 03:32 |
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Typeset the Manuscript |
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2023-02-07 06:47 |
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Publish the Manuscript Online |
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2023-02-15 00:44 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Potent bromodomain and extraterminal domain inhibitor JAB-8263 suppresses MYC expression and exerts anti-tumor activity in colorectal cancer models
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin-Mo Liu, Shao-You Xia, Wei Long, Hai-Jun Li, Gui-Qun Yang, Wen Sun, Song-Yan Li and Xiao-Hui Du |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81871317 |
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| Corresponding Author |
Xiao-Hui Du, MD, Chief Doctor, Deputy Director, Professor, Department of General Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100039, China. duxiaohuiplagh@sina.com |
| Key Words |
Bromodomain; Bromodomain and extraterminal domain inhibitor; Colorectal cancer; JAB-8263; MYC; p21 |
| Core Tip |
Treating with the bromodomain and extraterminal domain (BET) inhibitor JAB-8263, we found that MC38 cells undergo cell cycle arrest and apoptosis. In multiple human colorectal cancer cell lines, we found that JAB-8263 can down-regulate c-MYC expression and up-regulate p21 and p16 expression, associated with highly potent antiproliferative effects of JAB-8263 on colorectal cancer (CRC) cells. The conclusions obtained from in vitro experiments were verified in tumor mouse models that JAB-8263 effectively inhibits CRC growth with acceptable tolerance. Our studies suggested that BET can be a potential effective drug target for suppressing CRC growth, and BET inhibitor JAB-8263 can effectively suppress c-MYC expression and exert anti-tumor activity in CRC models. |
| Publish Date |
2023-02-15 00:44 |
| Citation |
Liu XM, Xia SY, Long W, Li HJ, Yang GQ, Sun W, Li SY, Du XH. Potent bromodomain and extraterminal domain inhibitor JAB-8263 suppresses MYC expression and exerts anti-tumor activity in colorectal cancer models. World J Gastrointest Oncol 2023; 15(2): 332-342 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i2/332.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i2.332 |
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