Publication Name	World Journal of Clinical Cases
Manuscript ID	81643
Country	Romania

Received	2022-11-18 20:07
Peer-Review Started	2022-11-18 20:09
To Make the First Decision
Return for Revision	2022-12-11 08:51
Revised	2022-12-19 20:31
Second Decision	2023-01-10 03:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-01-10 10:49
Articles in Press	2023-01-10 10:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-01-11 14:53
Publish the Manuscript Online	2023-01-26 17:44

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Dentistry, Oral Surgery & Medicine
Manuscript Type	Minireviews
Article Title	Could there be an interplay between periodontal changes and pancreatic malignancies?
Manuscript Source	Invited Manuscript
All Author List	Bogdan Silviu Ungureanu, Dorin Nicolae Gheorghe, Flavia Mirela Nicolae, Sandu Râmboiu, Petru Adrian Radu, Valeriu Marin Șurlin, Victor Dan Eugen Strâmbu, Dan Ionut Gheonea, Alexandra Roman and Petra Șurlin
Funding Agency and Grant Number
Corresponding Author	Flavia Mirela Nicolae, MD, Doctor, Researcher, Department of Periodontology, Research Center of Periodontal-Systemic Implications, University of Medicine and Pharmacy of Craiova, Str. Petru Rareș, nr. 2, Craiova 200349, Romania. flavia.nicolae23@yahoo.com
Key Words	Periodontal disease; Pancreatic cancer; Microbiome; Periodontitis; Periopathogens; Periodontal medicine
Core Tip	It has been suggested that gastroenterological malignancies may be promoted by hematogenous, enteral or lymphatic translocation of periopathogens. Periodontitis has been linked to at least 50% increased risk of pancreatic cancer (PC) and it could be considered a risk factor for this malignancy. Future risk of PC has been linked to the oral microbiome, specifically increased levels of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans and decreased relative abundance of Leptotrichia and Fusobacteria. By analyzing patterns in the microbiome composition throughout PC development and establishing strategies to enhance the cancer-associated microbial system, we can increase the efficacy of therapy.
Publish Date	2023-01-26 17:44
Citation	Ungureanu BS, Gheorghe DN, Nicolae FM, Râmboiu S, Radu PA, Șurlin VM, Strâmbu VDE, Gheonea DI, Roman A, Șurlin P. Could there be an interplay between periodontal changes and pancreatic malignancies? World J Clin Cases 2023; 11(3): 545-555
URL	https://www.wjgnet.com/2307-8960/full/v11/i3/545.htm
DOI	https://dx.doi.org/10.12998/wjcc.v11.i3.545

Full Article (PDF)	WJCC-11-545.pdf
Full Article (Word)	WJCC-11-545.docx
Manuscript File	81643_Auto_Edited-JLW.docx
Answering Reviewers	81643-Answering reviewers.pdf
Audio Core Tip	81643-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	81643-Conflict-of-interest statement.pdf
Copyright License Agreement	81643-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	81643-Language certificate.pdf
Peer-review Report	81643-Peer-review(s).pdf
Scientific Misconduct Check	81643-Bing-Fan JR-2.png
Scientific Editor Work List	81643-Scientific editor work list.pdf