Publication Name	World Journal of Gastroenterology
Manuscript ID	81680
Country	Portugal

Received	2022-11-19 17:58
Peer-Review Started	2022-11-19 17:59
To Make the First Decision
Return for Revision	2022-12-10 08:33
Revised	2022-12-18 21:15
Second Decision	2023-02-10 03:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-02-15 20:33
Articles in Press	2023-02-15 20:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-02-23 05:20
Publish the Manuscript Online	2023-02-28 11:21

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Early-onset colorectal cancer: A review of current knowledge
Manuscript Source	Invited Manuscript
All Author List	Margarida R Saraiva, Isadora Rosa and Isabel Claro
Funding Agency and Grant Number
Corresponding Author	Isadora Rosa, PhD, Medical Assistant, Department of Gastroenterology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Rua Prof Lima Bastos, Lisboa 1099-023, Portugal. isarosa@ipolisboa.min-saude.pt
Key Words	Colorectal cancer; Early-onset; Adenocarcinoma; Hereditary; Birth-cohort effect; Risk factors
Core Tip	The incidence of early-onset colorectal cancer (EO-CRC) has been surprisingly increasing worldwide and it has become a public health issue. Its clinical, genetic, molecular and histological characteristics suggest that this may be a distinct entity, with a more aggressive behaviour. However, both genetic and environmental risk factors seem to contribute to this observed epidemiological shift in CRC incidence. More evidence is needed in order to clarify EO-CRC aetiology and to develop screening and management strategies.
Publish Date	2023-02-28 11:21
Citation	Saraiva MR, Rosa I, Claro I. Early-onset colorectal cancer: A review of current knowledge. World J Gastroenterol 2023; 29(8): 1289-1303
URL	https://www.wjgnet.com/1007-9327/full/v29/i8/1289.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i8.1289

Full Article (PDF)	WJG-29-1289.pdf
Full Article (Word)	WJG-29-1289.docx
Manuscript File	81680_Auto_Edited-LM.docx
Answering Reviewers	81680-Answering reviewers.pdf
Audio Core Tip	81680-Audio core tip.mp4
Conflict-of-Interest Disclosure Form	81680-Conflict-of-interest statement.pdf
Copyright License Agreement	81680-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	81680-Language certificate.pdf
Peer-review Report	81680-Peer-review(s).pdf
Scientific Misconduct Check	81680-Bing-Wang JJ-2.png
Scientific Editor Work List	81680-Scientific editor work list.pdf
CrossCheck Report	81680-CrossCheck report.pdf