| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Identification of tumor antigens and immune subtypes of hepatocellular carcinoma for mRNA vaccine development
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tai-Liang Lu, Cheng-Long Li, Yong-Qiang Gong, Fu-Tao Hou and Chao-Wu Chen |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Chao-Wu Chen, MD, Chief Physician, Department of General Surgery, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, No. 61 Jiefang Xi Road, Furong District, Changsha 410005, Hunan Province, China. dr.chencw@hunnu.edu.cn |
| Key Words |
mRNA vaccine; Hepatocellular carcinoma; Immunotype; Antigens; Immune subtypes |
| Core Tip |
In this study, bioinformatics methods were used to explore novel hepatocellular carcinoma (HCC)-specific antigens for mRNA vaccine development and construct an immune subtype of HCC to select the appropriate vaccination population. Tumor-specific antigens were defined as highly expressed, genetically altered, and prognostic genes associated with antigen-presenting cell infiltration. AURKA, CCNB1, CDC25C, CDK1, TRIP13, PES1, MCM3, PPM1G, NEK2, KIF2C, PTTG1, KPNA2, and PRC1 were recognized candidate HCC antigens for mRNA vaccine development. The IS1 and IS3 immune subtypes of HCC were suitable populations for mRNA vaccination. RBP4, KNG1, METTL7A, F12, and ABAT were potential biomarkers for mRNA vaccines. |
| Publish Date |
2023-10-10 08:15 |
| Citation |
Lu TL, Li CL, Gong YQ, Hou FT, Chen CW. Identification of tumor antigens and immune subtypes of hepatocellular carcinoma for mRNA vaccine development. World J Gastrointest Oncol 2023; 15(10): 1717-1738 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i10/1717.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i10.1717 |
