Publication Name	World Journal of Clinical Cases
Manuscript ID	82368
Country	China

Received	2022-12-16 11:57
Peer-Review Started	2022-12-16 11:59
To Make the First Decision
Return for Revision	2023-02-28 08:37
Revised	2023-03-08 07:50
Second Decision	2023-04-11 03:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-04-12 01:40
Articles in Press	2023-04-12 01:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-05-06 01:44
Publish the Manuscript Online	2023-05-25 16:10

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Clinical and Translational Research
Article Title	Establishment of a prognostic model related to tregs and natural killer cells infiltration in bladder cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yan-Jie Yang, Xiao-Qing Xu, Yi-Chao Zhang, Peng-Cheng Hu and Wu-Xia Yang
Funding Agency and Grant Number
Corresponding Author	Wu-Xia Yang, The Graduate School/Department of Traditional Chinese Medicine, Tianjin Medical University/Tianjin Medical University General Hospital, Tianjin 300041, China. yangwuxia_09@tmu.edu.cn
Key Words	Natural killer cells; Tregs; Bladder cancer; Weighted gene coexpression network analysis; Bladder cancer Treatment; Immunotherapy; Computational molecular biology
Core Tip	Tregs are thought to be connected to tumor cells evading the immune system, which is linked to cancer patients' poor prognoses. Natural killer (NK) cells control different immune responses and show antitumor cytotoxicity without being previously sensitized. We determined the immunological scores of several cell types in Bladder urothelial carcinoma, discovered a gene set that was favorably connected with the Tregs score and negatively correlated with the NK cells score, and built a model that was related to prognosis. The model can predict the sensitivity of patients to chemotherapy and immunotherapy in addition to their prognosis for bladder cancers.
Publish Date	2023-05-25 16:10
Citation	Yang YJ, Xu XQ, Zhang YC, Hu PC, Yang WX. Establishment of a prognostic model related to Tregs and NK cells infiltration in bladder cancer. World J Clin Cases 2023; 11(15): 3444-3456
URL	https://www.wjgnet.com/2307-8960/full/v11/i15/3444.htm
DOI	https://dx.doi.org/10.12998/wjcc.v11.i15.3444

Full Article (PDF)	WJCC-11-3444-with-cover.pdf
Full Article (Word)	WJCC-11-3444.docx
Manuscript File	82368_Auto_Edited-LJH-JLW.docx
Answering Reviewers	82368-Answering reviewers.pdf
Audio Core Tip	82368-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	82368-Conflict-of-interest statement.pdf
Copyright License Agreement	82368-Copyright license agreement.pdf
Peer-review Report	82368-Peer-review(s).pdf
Scientific Misconduct Check	82368-Bing-Liu JH-2.png
Scientific Misconduct Check	82368-CrossCheck.png
Scientific Editor Work List	82368-Scientific editor work list.pdf