Publication Name	World Journal of Gastroenterology
Manuscript ID	82388
Country	China

Received	2022-12-17 13:37
Peer-Review Started	2022-12-17 13:39
To Make the First Decision
Return for Revision	2023-01-22 21:56
Revised	2023-02-01 06:12
Second Decision	2023-03-15 03:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-03-16 16:51
Articles in Press	2023-03-16 16:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-04-04 01:52
Publish the Manuscript Online	2023-04-13 08:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Parasitology
Manuscript Type	Basic Study
Article Title	Effect and mechanism of reactive oxygen species-mediated NOD-like receptor family pyrin domain-containing 3 inflammasome activation in hepatic alveolar echinococcosis
Manuscript Source	Unsolicited Manuscript
All Author List	Cai-Song Chen, Yao-Gang Zhang, Hai-Jiu Wang and Hai-Ning Fan
Funding Agency and Grant Number	Funding Agency Grant Number National Major Research and Development Project of “Precision Medicine Research” 2017YFC0909900 Qinghai Province Science and Technology Department Programme 2019-SF-131 Qinghai Province Health and Family Planning Commission Programme 2016-wjzd-04
Corresponding Author	Hai-Ning Fan, MD, Doctor, Professor, Department of Hepatobiliary and Pancreatic Surgery, Qinghai Province Research Key Laboratory for Echinococcosis, Affiliated Hospital of Qinghai University, No. 29 Tongren Road, Xining 810001, Qinghai Province, China. fanhaining6@yeah.net
Key Words	Hepatic alveolar echinococcosis; Inflammasome; Inflammation; Kupffer cell; NLR family pyrin domain-containing 3 protein; Reactive oxygen species
Core Tip	In recent years, the role of the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome in parasitic diseases has attracted widespread attention. However, the role and clinical significance of the NLRP3 inflammasome in Hepatic alveolar echinococcosis (HAE) remain unclear. Herein, we explored the mode of NLRP3 inflammasome activation in the tissues of patients with HAE, a rat model of HAE, rat Kupffer cells, and hepatocytes. Our experiments showed that inhibiting reactive oxygen species (ROS) production reduces NLRP3-caspase-1-IL-1β pathway activation. Decreased IL-1β expression alleviated inflammation and apoptosis rates in hepatocytes in HAE. We conclude that ROS-mediated NLRP3 inflammasome activation was a key factor leading to hepatocyte injury and triggering a cascade of inflammatory reactions. Therefore, ROS production may be a promising target for the treatment of HAE.
Publish Date	2023-04-13 08:14
Citation	Chen CS, Zhang YG, Wang HJ, Fan HN. Effect and mechanism of reactive oxygen species-mediated NOD-like receptor family pyrin domain-containing 3 inflammasome activation in hepatic alveolar echinococcosis. World J Gastroenterol 2023; 29(14): 2153-2171
URL	https://www.wjgnet.com/1007-9327/full/v29/i14/2153.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i14.2153

Full Article (PDF)	WJG-29-2153.pdf
Full Article (Word)	WJG-29-2153.docx
The ARRIVE Guidelines	82388-The-ARRIVE-Guidelines-revision.docx
Manuscript File	82388_Auto_Edited-LM.docx
Answering Reviewers	82388-Answering reviewers.pdf
Audio Core Tip	82388-Audio core tip.mp3
Biostatistics Review Certificate	82388-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	82388-Conflict-of-interest statement.pdf
Copyright License Agreement	82388-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	82388-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	82388-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	82388-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	82388-Language certificate.pdf
Peer-review Report	82388-Peer-review(s).pdf
Scientific Misconduct Check	82388-Bing-Chen YL-2.png
Scientific Editor Work List	82388-Scientific editor work list.pdf