Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	82636
Country	South Korea

Received	2022-12-24 13:58
Peer-Review Started	2022-12-24 13:59
To Make the First Decision
Return for Revision	2023-01-30 23:35
Revised	2023-02-10 12:59
Second Decision	2023-03-13 03:05
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-03-16 05:55
Articles in Press	2023-03-16 05:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-04-06 04:40
Publish the Manuscript Online	2023-04-12 08:10

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Clinical implications and perspectives of portal venous circulating tumor cells in pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Sung Woo Ko and Seung Bae Yoon
Funding Agency and Grant Number	Funding Agency Grant Number National Research Foundation of Korea NRF-2021 R1F1A1062255
Corresponding Author	Seung Bae Yoon, MD, PhD, Associate Professor, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, 1021, Tongil Ro, Eunpyeong-gu, Seoul 03312, South Korea. sbyoon@catholic.ac.kr
Key Words	Circulating tumor cell; Pancreatic cancer; Portal vein; Outcomes; Prognosis; Survival
Core Tip	Circulating tumor cells (CTCs) are emerging minimally invasive biomarkers for evaluating tumor characteristics; however, limited CTCs are detected in the peripheral blood. Portal venous blood, which does not undergo hepatic filtration, can theoretically harbor a large number of CTCs and can be safely assessed using endoscopic ultrasound. The efficacy of CTCs in portal venous blood have shown encouraging results (i.e., higher detection rate and better prediction of prognosis). Here, we provide an overview of CTCs in portal venous blood in the clinical context and future perspectives to enhance the role of portal CTCs as a valid biomarker in pancreatic cancer.
Publish Date	2023-04-12 08:10
Citation	Ko SW, Yoon SB. Clinical implications and perspectives of portal venous circulating tumor cells in pancreatic cancer. World J Gastrointest Oncol 2023; 15(4): 632-643
URL	https://www.wjgnet.com/1948-5204/full/v15/i4/632.htm
DOI	https://dx.doi.org/10.4251/wjgo.v15.i4.632

Full Article (PDF)	WJGO-15-632.pdf
Full Article (Word)	WJGO-15-632.docx
Manuscript File	82636_Auto_Edited-LM.docx
Answering Reviewers	82636-Answering reviewers.pdf
Audio Core Tip	82636-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	82636-Conflict-of-interest statement.pdf
Copyright License Agreement	82636-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	82636-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	82636-Language certificate.pdf
Peer-review Report	82636-Peer-review(s).pdf
Scientific Editor Work List	82636-Scientific editor work list.pdf
CrossCheck Report	82636-CrossCheck report.pdf