Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	82684
Country	China

Received	2022-12-26 09:07
Peer-Review Started	2022-12-26 09:09
To Make the First Decision
Return for Revision	2023-03-13 05:44
Revised	2023-03-15 14:24
Second Decision	2023-04-14 03:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-04-14 09:51
Articles in Press	2023-04-14 09:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-05-05 00:51
Publish the Manuscript Online	2023-05-12 09:13

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Immuno-oncology-microbiome axis of gastrointestinal malignancy
Manuscript Source	Invited Manuscript
All Author List	Quan Lin, Shi-Wei Guan and Hai-Bo Yu
Funding Agency and Grant Number
Corresponding Author	Hai-Bo Yu, MD, Chief Doctor, Department of Surgery, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, No. 252 Baili East Road, Wenzhou 325000, Zhejiang Province, China. yuhaibozjwz@163.com
Key Words	Gut microbiome; Intratumor microbiome; Gastrointestinal malignancy; Tumor microenvironment; Immunity; Therapy
Core Tip	The gut and intratumor microbiome can influence tumor progression by modulating host metabolism and the immune and immune tone of the tumor microenvironment, which is defined as the immuno-oncology-microbiome (IOM) axis. The proposed the IOM axis provides a new target for tumor microbiome and tumor immunity. Current studies have shown that immunotherapy with fecal microbiota transplantation or microbial metabolism have certain effects. This review aims to explore the mechanism of the IOM axis of gastrointestinal malignancies, to reveal the mechanism and progress of gut and intratumor microbiome in gastrointestinal malignancies. Providing new insights into the research related to gastrointestinal malignancies.
Publish Date	2023-05-12 09:13
Citation	Lin Q, Guan SW, Yu HB. Immuno-oncology-microbiome axis of gastrointestinal malignancy. World J Gastrointest Oncol 2023; 15(5): 757-775
URL	https://www.wjgnet.com/1948-5204/full/v15/i5/757.htm
DOI	https://dx.doi.org/10.4251/wjgo.v15.i5.757

Full Article (PDF)	WJGO-15-757.pdf
Full Article (Word)	WJGO-15-757.docx
Manuscript File	82684_Auto_Edited-JLW.doc
Answering Reviewers	82684-Answering reviewers.pdf
Audio Core Tip	82684-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	82684-Conflict-of-interest statement.pdf
Copyright License Agreement	82684-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	82684-Language certificate.pdf
Peer-review Report	82684-Peer-review(s).pdf
Scientific Misconduct Check	82684-Bing-Wang JJ-2.png
Scientific Editor Work List	82684-Scientific editor work list.pdf