| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Immunotherapy in glioblastoma treatment: Current state and future prospects
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Samuel Luca Rocha Pinheiro, Fabian Fellipe Bueno Lemos, Hanna Santos Marques, Marcel Silva Luz, Luís Guilherme de Oliveira Silva, Clara Faria Souza Mendes dos Santos, Karolaine da Costa Evangelista, Mariana Santos Calmon, Matheus Sande Loureiro and Fabrício Freire de Melo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Council for Scientific and Technological Development, CNPq |
|
| Bahia State Research Support Foundation, FAPESB |
|
|
| Corresponding Author |
Fabrício Freire de Melo, PhD, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Hormindo Barros, 58, Quadra 17, Lote 58, Vitória da Conquista 45029-094, Bahia, Brazil. freiremeloufba@gmail.com |
| Key Words |
Glioblastoma; Immunotherapy; Tumor microenvironment; Chimeric antigen receptor T cell; Oncolytic viruses; Immune-checkpoint inhibitors; Brain cancer |
| Core Tip |
This study aims to review the ongoing status and improvement made in immunotherapy for glioblastoma, a malignant brain tumor. Thus, this review goes through the general concepts of the tumor microenvironment, standard treatment and its limitations and immune targeting promising methods, such as Chimeric antigen receptor T-Cell therapy, immune checkpoint inhibitors, cytokine-based treatment, oncolytic virus and vaccine-based techniques. Finally, it is explained some methods to surpass the various challenges, and future prospects in this field. |
| Publish Date |
2023-04-21 03:41 |
| Citation |
Rocha Pinheiro SL, Lemos FFB, Marques HS, Silva Luz M, de Oliveira Silva LG, Faria Souza Mendes dos Santos C, da Costa Evangelista K, Calmon MS, Sande Loureiro M, Freire de Melo F. Immunotherapy in glioblastoma treatment: Current state and future prospects. World J Clin Oncol 2023; 14(4): 138-159 |
| URL |
https://www.wjgnet.com/2218-4333/full/v14/i4/138.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v14.i4.138 |
