Publication Name	World Journal of Medical Genetics
Manuscript ID	8339
Country	United States

Received	2013-12-26 10:09
Peer-Review Started	2013-12-26 12:01
To Make the First Decision	2014-03-12 17:05
Return for Revision	2014-03-21 20:31
Revised
Second Decision	2014-05-16 17:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-16 17:48
Articles in Press	2014-05-23 12:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-03 17:47
Publish the Manuscript Online	2014-09-19 20:46

ISSN	2220-3184 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Molecular genetics of gastric adenocarcinoma in clinical practice
Manuscript Source	Invited Manuscript
All Author List	Margaret Cho, Ogechukwu Eze and Ruliang Xu
Funding Agency and Grant Number
Corresponding Author	Ruliang Xu, MD, PhD, Department of Pathology, New York University Langone Medical Center, 550 First Avenue, New York, NY 10016, United States. ruliang.xu@nyumc.org
Key Words	Molecular genetics; Lauren classification; Intestinal type gastric cancer; Diffuse type gastric cancer; Molecular Biomarker
Core Tip	Intestinal and diffuse cell types of gastric carcinoma have a significant difference in clinical outcome with different molecular pathogenetic pathways. Intestinal type gastric carcinoma (GC) is associated with chromosomal and/or microsatellite instability, mutation of tumor suppressor genes, and loss of heterozygosity. Diffuse type GC is commonly associated with mutation of the E-cadherin gene, and a manifestation of the hereditary gastric cancer syndrome. Detection of certain mutations may aid in early diagnosis, screening, and prognostication of GC, and common genetic alterations may offer therapeutic targets for treatment. Furthermore, potential therapeutic biomarkers for GC are under investigation and may hold future promise.
Publish Date	2014-09-19 20:46
Citation	Cho M, Eze O, Xu R. Molecular genetics of gastric adenocarcinoma in clinical practice. World J Med Genet 2014; 4(3): 58-68
URL	http://www.wjgnet.com/2220-3184/full/v4/i3/58.htm
DOI	http://dx.doi.org/10.5496/wjmg.v4.i3.58

Full Article (PDF)	WJMG-4-58.pdf
Full Article (Word)	WJMG-4-58.doc
Manuscript File	8339-Review.doc
Answering Reviewers	8339-Answering reviewers.pdf
Copyright License Agreement	8339-Copyright assignment.pdf
Peer-review Report	8339-Peer review(s).pdf
Scientific Editor Work List	8339-Scientific editor work list.pdf