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8/28/2014 2:00:00 PM | Browse: 620 | Download: 650
Publication Name World Journal of Gastroenterology
Manuscript ID 8355
Country/Territory China
Received
2013-12-26 16:08
Peer-Review Started
2013-12-27 10:02
To Make the First Decision
2014-01-15 11:15
Return for Revision
2014-01-20 10:45
Revised
Second Decision
2014-04-23 09:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-04-23 10:16
Articles in Press
2014-05-23 10:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-07-15 16:49
Typeset the Manuscript
2014-08-28 09:43
Publish the Manuscript Online
2014-08-29 11:57
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Autobiography
Article Title Effect of GP73 silencing on proliferation and apoptosis in hepatocellular cancer
Manuscript Source Unsolicited Manuscript
All Author List Yu-Long Zhang, You-Cheng Zhang, Wei Han, Yu-Min Li, Geng-Nian Wang, Shao Yuan, Feng-Xian Wei, Jia-Feng Wang, Jian-Jun Jiang and Ya-Wu Zhang
Funding Agency and Grant Number
Funding Agency Grant Number
Gansu Provincial-level Key Laboratory of Digestive System Tumors Open projects Research Fund lzujbky-2011-t03
Corresponding Author Correspondence to: You-Cheng Zhang, MD, PhD, Department of General Surgery, Lanzhou University Second Hospital, Cuiyingmen 82, Chengguan District, Lanzhou 730030, Gansu Province, China. zhangyouchengphd@163.com
Key Words Hepatocellular carcinoma; Golgi protein-73; Cell proliferation; Apoptosis
Core Tip Stealth RNAi targeting Golgi protein (GP)73 gene sequence markedly reduced the expression of GP73 gene. Reduction of GP73 in Hep G2 cells and Bel7402 cells inhibited cell proliferation and induced apoptosis, however, terminal apoptosis occurred in Hep G2 cells, but early apoptosis occurred in Bel7402 cells. Reduced expression of GP73 gene might lead to a reduction in Bcl-2/ Bax ratio, an increase in cytochrome c, but a reduction in capase-3. GP73 might play an important role in proliferation and apoptosis in Hep G2 and Bel7402 cells.
Publish Date 2014-08-29 11:57
Citation Zhang YL, Zhang YC, Han W, Li YM, Wang GN, Yuan S, Wei FX, Wang JF, Jiang JJ, Zhang YW. Effect of GP73 silencing on proliferation and apoptosis in hepatocellular cancer. World J Gastroenterol 2014; 20(32): 11287-11296
URL http://www.wjgnet.com/1007-9327/full/v20/i32/11287.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i32.11287
Full Article (PDF) WJG-20-11287.pdf
Full Article (Word) WJG-20-11287.doc
Manuscript File 8355-Review.doc
Answering Reviewers 8355-Answering reviewers.pdf
Copyright License Agreement 8355-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 8355-Language certificate.pdf
Peer-review Report 8355-Peer reviews.pdf
Scientific Editor Work List 8355-Scientific editor work list.doc