| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Dihydroergotamine ameliorates liver fibrosis by targeting transforming growth factor β type II receptor
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ke-Xin Zheng, Shou-Li Yuan, Meng Dong, Han-Lin Zhang, Xiao-Xiao Jiang, Chun-Long Yan, Rong-Cai Ye, Hui-Qiao Zhou, Li Chen, Rui Jiang, Zi-Yu Cheng, Zhi Zhang, Qi Wang, Wan-Zhu Jin and Wen Xie |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Special Research Project for Capital Health Development |
2022-2-2174 |
| the Beijing Municipal Science and Technology Commission |
Z191100007619037 |
|
| Corresponding Author |
Wen Xie, MD, Doctor, Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing 100015, China. xiewen6218@163.com |
| Key Words |
Liver fibrosis; Transforming growth factor β (TGFβ) signaling pathway; TGFβ type II receptor (TGFβR2); Virtual screening; Drug-repurposing; Dihydroergotamine |
| Core Tip |
An effective and safe drug for treating liver fibrosis is urgently needed in current clinical practice. Here, we investigated and discovered that dihydroergotamine (DHE) could alleviate liver fibrosis by specific binding of transforming growth factor β type II receptor (TGFβR2) to disrupt the binding of TGFβR2 with TGFβ1, and ultimately suppressing its downstream TGFβ signaling pathway. DHE may be an effective anti-liver fibrosis drug, which could be employed in liver cirrhotic patients. |
| Publish Date |
2023-05-26 08:34 |
| Citation |
Zheng KX, Yuan SL, Dong M, Zhang HL, Jiang XX, Yan CL, Ye RC, Zhou HQ, Chen L, Jiang R, Cheng ZY, Zhang Z, Wang Q, Jin WZ, Xie W. Dihydroergotamine ameliorates liver fibrosis by targeting transforming growth factor β type II receptor. World J Gastroenterol 2023; 29(20): 3103-3118 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i20/3103.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i20.3103 |
