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6/27/2023 6:08:55 AM | Browse: 189 | Download: 833
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Received |
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2023-02-09 05:15 |
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Peer-Review Started |
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2023-02-09 05:17 |
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To Make the First Decision |
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Return for Revision |
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2023-04-10 20:54 |
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Revised |
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2023-04-18 08:33 |
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Second Decision |
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2023-05-04 03:13 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-05-05 17:14 |
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Articles in Press |
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2023-05-05 17:14 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-05-31 00:20 |
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Publish the Manuscript Online |
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2023-06-26 14:09 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Dentistry, Oral Surgery & Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Single cell RNA sequencing reveals mesenchymal heterogeneity and critical functions of Cd271 in tooth development
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Yan Zhang, Feng Li, Xiao-Ke Zeng, Yan-Hui Zou, Bing-Bing Zhu, Jia-Jia Ye, Yun-Xiao Zhang, Qiu Jin and Xin Nie |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Medical Health Science and Technology Project of Zhejiang Province |
2023KY155 |
| National Natural Science Foundation of China (General Program) |
31870971 |
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| Corresponding Author |
Xin Nie, PhD, Professor, School & Hospital of Stomatology, Wenzhou Medical University, Xueyuan West Road, Lucheng District, Wenzhou 325027, Zhejiang Province, China. dr.xinnie@qq.com |
| Key Words |
Cd271; Mesenchymal stem cells; Single cell RNA sequencing; Osteogenesis; Mineralization; Tooth development |
| Core Tip |
Our study reveals the following findings: (1) High cellular heterogeneity and molecular details; (2) Significant functional and signaling differences between cell types; (3) Novel subclusters of mesenchymal stem cells; and (4) Crucial cell-cell interactions of mesenchymal subpopulations. We provided new insights into the biological features of mesenchymal stem cells at the single cell level. Our findings contribute to thorough exploration of the mechanism of Cd271 in regulating odontogenesis and osteogenesis which add to the theory of tooth development. |
| Publish Date |
2023-06-26 14:09 |
| Citation |
Zhang YY, Li F, Zeng XK, Zou YH, Zhu BB, Ye JJ, Zhang YX, Jin Q, Nie X. Single cell RNA sequencing reveals mesenchymal heterogeneity and critical functions of Cd271 in tooth development. World J Stem Cells 2023; 15(6): 589-606 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i6/589.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i6.589 |
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