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7/12/2023 1:05:56 PM | Browse: 174 | Download: 629
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Received |
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2023-02-11 17:35 |
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Peer-Review Started |
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2023-02-11 17:39 |
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To Make the First Decision |
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Return for Revision |
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2023-03-28 23:07 |
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Revised |
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2023-04-11 03:20 |
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Second Decision |
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2023-05-08 03:12 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-05-08 08:38 |
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Articles in Press |
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2023-05-08 08:38 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-07-03 11:03 |
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Publish the Manuscript Online |
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2023-07-12 11:13 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Application of G-quadruplex targets in gastrointestinal cancers: Advancements, challenges and prospects
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zong-Qiang Han and Li-Na Wen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81803773 |
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| Corresponding Author |
Li-Na Wen, Doctor, Research Associate, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyi Road, Yangfangdian Street, Haidian District, Beijing 100038, China. wenlina3074@bjsjth.cn |
| Key Words |
G-quadruplex; Pancreatic cancer; Liver cancer; Gastric cancer; Colorectal cancer; Gastrointestinal stromal tumor |
| Core Tip |
G-quadruplexes are widely distributed in the human genome and have many functions. G-quadruplexes play double regulatory roles in transcription and translation. We focus on G-quadruplexes as novel therapeutic targets for gastrointestinal cancers. We summarize the application basis of G-quadruplexes in gastrointestinal cancers, including their distribution sites, structural characteristics, and physiological functions. We describe the current status of applications for the treatment of esophageal cancer, pancreatic cancer, hepatocellular carcinoma, gastric cancer, colorectal cancer, and gastrointestinal stromal tumors, as well as the associated challenges. We review prospective clinical applications of G-quadruplex targets, providing references for targeted treatment in gastrointestinal cancers. |
| Publish Date |
2023-07-12 11:13 |
| Citation |
Han ZQ, Wen LN. Application of G-quadruplex targets in gastrointestinal cancers: Advancements, challenges and prospects. World J Gastrointest Oncol 2023; 15(7): 1149-1173 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i7/1149.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i7.1149 |
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