| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Fibroblast growth factor 15, induced by elevated bile acids, mediates the improvement of hepatic glucose metabolism after sleeve gastrectomy
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Meng Wei, Wei-Bo Cao, Ru-Dong Zhao, Dan-Ping Sun, Yi-Ze Liang, Ya-Di Huang, Ze-Wei Cheng, Jun Ouyang, Wen-Shuo Yang and Wen-Bin Yu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81600617 |
|
| Corresponding Author |
Wen-Bin Yu, MD, PhD, Chief Doctor, Professor, Department of General Surgery, Qilu Hospital of Shandong University, No. 107 Wenhua Xi Road, Jinan 250012, Shandong Province, China. wenbin_yu2003@163.com |
| Key Words |
Sleeve gastrectomy; Fibroblast growth factor 15; Bile acids; Hepatic glucose metabolism; Type 2 diabetes mellitus |
| Core Tip |
Sleeve gastrectomy (SG) improves hepatic glucose metabolism and alleviates type 2 diabetes mellitus through the intestine-liver crosstalk mediated by fibroblast growth factor 15 (FGF15). Following SG, bile acids are elevated, inducing the expression and secretion of FGF15 via the activation of farnesoid X receptor in the ileum. FGF15 then acts as an endocrine factor to promote glycogen synthesis and inhibit gluconeogenesis in the liver by specifically stimulating hepatic FGF receptor 4 and its corresponding signaling pathways. |
| Publish Date |
2023-06-01 13:04 |
| Citation |
Wei M, Cao WB, Zhao RD, Sun DP, Liang YZ, Huang YD, Cheng ZW, Ouyang J, Yang WS, Yu WB. Fibroblast growth factor 15, induced by elevated bile acids, mediates the improvement of hepatic glucose metabolism after sleeve gastrectomy. World J Gastroenterol 2023; 29(21): 3280-3291 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i21/3280.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i21.3280 |
