Publication Name	World Journal of Hepatology
Manuscript ID	83908
Country	Türkiye

Received	2023-02-15 12:02
Peer-Review Started	2023-02-15 12:05
To Make the First Decision
Return for Revision	2023-03-09 14:56
Revised	2023-03-22 17:26
Second Decision	2023-04-18 02:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-04-18 08:19
Articles in Press	2023-04-18 08:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-06-16 08:16
Publish the Manuscript Online	2023-06-25 14:17

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pathology
Manuscript Type	Minireviews
Article Title	Tumor budding as a potential prognostic marker in determining the behavior of primary liver cancers
Manuscript Source	Invited Manuscript
All Author List	Betul Unal, Mennan Yigitcan Celik, Elif Ocak Gedik, Cumhur Ibrahim Bassorgun and Gulsum Ozlem Elpek
Funding Agency and Grant Number
Corresponding Author	Gulsum Ozlem Elpek, MD, Professor, Department of Pathology, Akdeniz University Medical Scholl, Dumlupinar Bulvarı, Antalya 07070, Türkiye. elpek@akdeniz.edu.tr
Key Words	Tumor budding; Hepatocellular carcinoma; Cholangiocarcinoma; Prognosis; Liver cancer; Epithelial-mesenchymal transition
Core Tip	This review aims to present recent data on the potential of tumor budding (TB) in determining tumor behavior in hepatocellular carcinoma and cholangiocarcinoma. Although the evidence from the published literature indicates that TB may be a promising prognostic factor for primary liver tumors, more multidisciplinary studies are needed to draw a conclusion. Besides, different assessment techniques in previous investigations indicate that a standard method should be established to provide a solid basis for further studies that may clarify whether this parameter will be included in pathology report protocols as in colorectal carcinoma in the near future.
Publish Date	2023-06-25 14:17
Citation	Unal B, Celik MY, Gedik EO, Bassorgun CI, Elpek GO. Tumor budding as a potential prognostic marker in determining the behavior of primary liver cancers. World J Hepatol 2023; 15(6): 775-785
URL	https://www.wjgnet.com/1948-5182/full/v15/i6/775.htm
DOI	https://dx.doi.org/10.4254/wjh.v15.i6.775

Full Article (PDF)	WJH-15-775-with-cover.pdf
Full Article (Word)	WJH-15-775.docx
Manuscript File	83908_Auto_Edited-JLW.docx
Answering Reviewers	83908-Answering reviewers.pdf
Audio Core Tip	83908-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	83908-Conflict-of-interest statement.pdf
Copyright License Agreement	83908-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	83908-Language certificate.pdf
Peer-review Report	83908-Peer-review(s).pdf
Scientific Misconduct Check	83908-Bing-Ma YJ-2.jpg
Scientific Editor Work List	83908-Scientific editor work list.pdf
CrossCheck Report	83908-CrossCheck Report.pdf