| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Luka Kalogjera, Ivan Krezic, Ivan Maria Smoday, Hrvoje Vranes, Helena Zizek, Haidi Yago, Katarina Oroz, Vlasta Vukovic, Ivana Kavelj, Luka Novosel, Slavica Zubcic, Ivan Barisic, Lidija Beketic Oreskovic, Sanja Strbe, Marko Sever, Ivica Sjekavica, Anita Skrtic, Alenka Boban Blagaic, Sven Seiwerth and Predrag Sikiric |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Predrag Sikiric, MD, PhD, Full Professor, Department of Pharmacology, School of Medicine, 11 Salata, Zagreb 10000, Croatia. sikiric@mef.hr |
| Key Words |
Stomach perforation; General occlusion/occlusion-like syndrome; Stable gastric pentadecapeptide BPC 157; Cytoprotection; Therapy; Rats |
| Core Tip |
Rats with perforated stomachs exhibited the rapidly emerging severe occlusion/occlusion-like syndrome, an innate general vascular and multiorgan failure, peripherally and centrally. The pentadecapeptide BPC 157 application into stomach defects was efficacious therapy. With an activated azygos vein-rescuing pathway, there was cause-consequence counteraction of lesions in the brain (swelling, hemorrhage), heart (congestion), lung (hemorrhage), and congestion in the liver, kidney, and gastrointestinal tract. Whole occlusion/occlusion-like syndrome, arrhythmias, blood pressure disturbances (intracranial (superior sagittal sinus), portal and caval hypertension, and aortal hypotension), major vessel failure, and widespread thrombosis, Virchow triad circumstances peripherally and centrally were all attenuated/eliminated by BPC 157 therapy. |
| Publish Date |
2023-07-13 08:46 |
| Citation |
Kalogjera L, Krezic I, Smoday IM, Vranes H, Zizek H, Yago H, Oroz K, Vukovic V, Kavelj I, Novosel L, Zubcic S, Barisic I, Beketic Oreskovic L, Strbe S, Sever M, Sjekavica I, Skrtic A, Boban Blagaic A, Seiwerth S, Sikiric P. Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect. World J Gastroenterol 2023; 29(27): 4289-4316 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i27/4289.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i27.4289 |
