Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	84494
Country	Japan

Received	2023-03-20 02:32
Peer-Review Started	2023-03-20 02:36
To Make the First Decision
Return for Revision	2023-04-13 01:40
Revised	2023-04-20 04:31
Second Decision	2023-05-22 03:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-05-22 09:03
Articles in Press	2023-05-22 09:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-07-05 00:11
Publish the Manuscript Online	2023-07-21 14:21

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Surgery
Manuscript Type	Basic Study
Article Title	Histological study of the structural layers around the esophagus in the lower mediastinum
Manuscript Source	Unsolicited Manuscript
All Author List	Toshifumi Saito, Satoru Muro, Hisashi Fujiwara, Yuya Umebayashi, Yuya Sato, Masanori Tokunaga, Keiichi Akita and Yusuke Kinugasa
Funding Agency and Grant Number
Corresponding Author	Hisashi Fujiwara, MD, PhD, Surgeon, Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku 113-8519, Tokyo, Japan. fujsrg1@tmd.ac.jp
Key Words	Esophagogastric junction; Histology; Mediastinum; Adenocarcinoma; Esophageal cancer; Gastric cancer
Core Tip	The transhiatal procedure including lower mediastinal lymph node (LN) dissection is widely performed to treat esophagogastric junction (EGJ) adenocarcinoma. However, microanatomy of the lower mediastinum is unclear and the classification of lower mediastinal LNs is obscure. Therefore, we performed a histological study to investigate the microanatomy of the lower mediastinum in seven cadavers. We identified two fasciae surrounding the esophagus in the lower mediastinum and classified the periesophageal lower mediastinal tissue into three areas based on these fasciae. LNs were found within all classified areas. These data provide useful landmarks for EGJ adenocarcinoma surgery.
Publish Date	2023-07-21 14:21
Citation	Saito T, Muro S, Fujiwara H, Umebayashi Y, Sato Y, Tokunaga M, Akita K, Kinugasa Y. Histological study of the structural layers around the esophagus in the lower mediastinum. World J Gastrointest Surg 2023; 15(7): 1331-1339
URL	https://www.wjgnet.com/1948-9366/full/v15/i7/1331.htm
DOI	https://dx.doi.org/10.4240/wjgs.v15.i7.1331

Full Article (PDF)	WJGS-15-1331-with-cover.pdf
Full Article (Word)	WJGS-15-1331.docx
Manuscript File	84494_Auto_Edited-JLW.docx
Answering Reviewers	84494-Answering reviewers.pdf
Audio Core Tip	84494-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	84494-Conflict-of-interest statement.pdf
Copyright License Agreement	84494-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	84494-Institutional review board statement.PDF
Non-Native Speakers of English Editing Certificate	84494-Language certificate.pdf
Supplementary Material	84494-Informed consent statement.pdf
Peer-review Report	84494-Peer-review(s).pdf
Scientific Misconduct Check	84494-Bing-Li L-2.png
Scientific Editor Work List	84494-Scientific editor work list.pdf