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8/25/2023 8:38:06 AM | Browse: 142 | Download: 498
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Received |
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2023-03-28 10:23 |
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Peer-Review Started |
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2023-03-28 10:24 |
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To Make the First Decision |
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Return for Revision |
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2023-06-25 06:32 |
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Revised |
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2023-06-29 14:55 |
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Second Decision |
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2023-07-13 02:55 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-07-14 18:56 |
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Articles in Press |
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2023-07-14 18:56 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-08-23 02:44 |
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Publish the Manuscript Online |
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2023-08-25 07:59 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Constitutive aryl hydrocarbon receptor facilitates the regenerative potential of mouse bone marrow mesenchymal stromal cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing Huang, Yi-Ning Wang and Yi Zhou |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82001014 |
| National Natural Science Foundation of China |
82071090 |
| Hubei Provincial Natural Science Foundation of China |
2022CFB115 |
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| Corresponding Author |
Yi Zhou, PhD, Associate Professor, Chief Doctor, State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, No. 237 Luoyu Road, Hongshan District, Wuhan 430079, Hubei Province, China. dryizhou@whu.edu.cn |
| Key Words |
Aryl hydrocarbon receptor; Bone marrow mesenchymal stromal cells; Osteogenesis; Macrophage; Signal transducer and activator of transcription 3; Interaction |
| Core Tip |
Aryl hydrocarbon receptor (AhR) was positively expressed in murine bone marrow tissue and bone marrow mesenchymal stromal cells (BMSCs). In vitro, overexpression of AhR enhanced the osteogenic potential of mouse BMSCs. Additionally, AhR-overexpressed BMSCs had an increased ability to polarize macrophages to an anti-inflammatory phenotype. While knockdown of AhR showed the opposite effects. Mechanistically, the beneficial effects of AhR were partially dependent on increased phosphorylation of signal transducer and activator of transcription 3. This study suggests that AhR might be a target for achieving optimal bone regeneration in mouse BMSCs-based tissue engineering. |
| Publish Date |
2023-08-25 07:59 |
| Citation |
Huang J, Wang YN, Zhou Y. Constitutive aryl hydrocarbon receptor facilitates the regenerative potential of mouse bone marrow mesenchymal stromal cells. World J Stem Cells 2023; 15(8): 807-820 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i8/807.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i8.807 |
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