Publication Name	World Journal of Gastroenterology
Manuscript ID	84666
Country	China

Received	2023-03-23 13:10
Peer-Review Started	2023-03-23 13:14
To Make the First Decision
Return for Revision	2023-06-17 11:21
Revised	2023-06-28 15:05
Second Decision	2023-07-14 02:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-07-17 01:27
Articles in Press	2023-07-17 01:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-07-21 03:08
Publish the Manuscript Online	2023-08-02 09:29

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Predictors and optimal management of tumor necrosis factor antagonist nonresponse in inflammatory bowel disease: A literature review
Manuscript Source	Invited Manuscript
All Author List	Liang-Fang Wang, Ping-Run Chen, Si-Ke He, Shi-Hao Duan and Yan Zhang
Funding Agency and Grant Number
Corresponding Author	Yan Zhang, MD, PhD, Chief Physician, Doctor, Professor, Department of Gastroenterology and Hepatology, West China Hospita, Sichuan University, No. 37 Guoxue Street, Chengdu 610041, Sichuan Province, China. hxzyan@163.com
Key Words	Predictor; Management; Tumor necrosis factor antagonist; Primary nonresponse; Secondary nonresponse; Inflammatory bowel disease
Core Tip	Tumor necrosis factor-α (TNF-α) antagonists play an essential role in the management of inflammatory bowel disease (IBD). However, a significant number of patients experience primary or secondary nonresponse to these drugs. Here, we summarize relevant predictors of anti-TNF nonresponse in IBD and discuss the next steps for treating patients with primary or secondary nonresponse to anti-TNF agents.
Publish Date	2023-08-02 09:29
Citation	Wang LF, Chen PR, He SK, Duan SH, Zhang Y. Predictors and optimal management of tumor necrosis factor antagonist nonresponse in inflammatory bowel disease: A literature review. World J Gastroenterol 2023; 29(29): 4481-4498
URL	https://www.wjgnet.com/1007-9327/full/v29/i29/4481.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i29.4481

Full Article (PDF)	WJG-29-4481-with-cover.pdf
Full Article (Word)	WJG-29-4481.docx
Manuscript File	84666_Auto_Edited-JLW.docx
Answering Reviewers	84666-Answering reviewers.pdf
Audio Core Tip	84666-Audio core tip.aac
Conflict-of-Interest Disclosure Form	84666-Conflict-of-interest statement.pdf
Copyright License Agreement	84666-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	84666-Language certificate.pdf
Supplementary Material	84666-Supplementary material.pdf
Peer-review Report	84666-Peer-review(s).pdf
Scientific Misconduct Check	84666-Bing-Yan JP-2.png
Scientific Editor Work List	84666-Scientific editor work list.pdf