Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	84756
Country	India

Received	2023-03-27 09:48
Peer-Review Started	2023-03-27 09:50
To Make the First Decision
Return for Revision	2023-04-11 09:33
Revised	2023-05-19 08:29
Second Decision	2023-05-29 03:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-05-31 00:51
Articles in Press	2023-05-31 00:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-05-31 07:47
Publish the Manuscript Online	2023-06-01 09:43

ISSN	2150-5330 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of p53 suppression in the pathogenesis of hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Heena B Choudhary, Satish K Mandlik and Deepa S Mandlik
Funding Agency and Grant Number
Corresponding Author	Deepa S Mandlik, PhD, Assistant Professor, Department of Pharmacology, BVDU, Poona College of Pharmacy, Kothrud, Pune 411038, Maharashtra, India. deepa.mandlik@bharatividyapeeth.edu
Key Words	Hepatocellular carcinoma; p53; Tumour suppressor gene; Murine double minute 2; Chemoresistance
Core Tip	This review articles covers all the points related to p53 gene suppression in the pathogenesis of hepatocellular carcinoma. The review manuscript also includes information about tumour suppressor P53, pathogenesis of P53-associated hepatocellular carcinoma (HCC), role of P53 in mechanisms of hepatocarcinogenesis, roles of P53 in extrinsic factor-induced liver carcinogenesis, relationship between hepatitis C virus core protein and P53 in HCC, other mechanisms of progression to cirrhosis and HCC.
Publish Date	2023-06-01 09:43
Citation	Choudhary HB, Mandlik SK, Mandlik DS. Role of p53 suppression in the pathogenesis of hepatocellular carcinoma. World J Gastrointest Pathophysiol 2023; 14(3): 46-70
URL	https://www.wjgnet.com/2150-5330/full/v14/i3/46.htm
DOI	https://dx.doi.org/10.4291/wjgp.v14.i3.46

Full Article (PDF)	WJGP-14-46.pdf
Full Article (Word)	WJGP-14-46.docx
Manuscript File	84756_Auto_Edited-JLW.docx
Answering Reviewers	84756-Answering reviewers.pdf
Audio Core Tip	84756-Audio core tip.mp4
Conflict-of-Interest Disclosure Form	84756-Conflict-of-interest statement.pdf
Copyright License Agreement	84756-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	84756-Language certificate.pdf
Peer-review Report	84756-Peer-review(s).pdf
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Scientific Editor Work List	84756-Scientific editor work list.pdf
CrossCheck Report	84756-CrossCheck report.pdf
CrossCheck Report	84756-CrossCheck.png