| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Bioenergetic alteration in gastrointestinal cancers: The good, the bad and the ugly
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yu-De Chu, Chun-Wei Chen, Ming-Wei Lai, Siew-Na Lim and Wey-Ran Lin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Science and Technology, Taiwan |
MOST-110-2314-B-182A-095- |
| Ministry of Science and Technology, Taiwan |
MOST-111-2314-B-182A-126- |
| Chang Gung Memorial Hospital, Linkou Branch, Taiwan |
CMRPG3K2292 |
| Chang Gung Memorial Hospital, Linkou Branch, Taiwan |
CMRPG3J0693 |
| Chang Gung Memorial Hospital, Linkou Branch, Taiwan |
CORPG3J0531 |
| Chang Gung Memorial Hospital, Linkou Branch, Taiwan |
CORPG3L0261 |
| Chang Gung Memorial Hospital, Linkou Branch, Taiwan |
CORPG3J0501 |
| Chang Gung Memorial Hospital, Linkou Branch, Taiwan |
CMRPG3K0771 |
|
| Corresponding Author |
Wey-Ran Lin, AGAF, MD, PhD, Professor, Department of Gastroenterology and Hepatology, Linkou Chang Gung Memorial Hospital, No. 5 Fu-Shin Street, Taoyuan 333, Taiwan. t12360@adm.cgmh.org.tw |
| Key Words |
Energy metabolism; Mitochondria; Hypoxia; Oxidative phosphorylation; Glycolysis; Gastrointestinal Neoplasms |
| Core Tip |
This review discusses the bioenergetic alteration and metabolic reprogramming in gastrointestinal (GI) cancers, including the interplay between aerobic glycolysis, tricarboxylic acid cycle, and oxidative phosphorylation. The review also highlights potential strategies for targeting bioenergetic regulators for anti-cancer therapy in GI cancers, summarizing efficacy and challenges with several drugs. |
| Publish Date |
2023-08-02 09:29 |
| Citation |
Chu YD, Chen CW, Lai MW, Lim SN, Lin WR. Bioenergetic alteration in gastrointestinal cancers: The good, the bad and the ugly. World J Gastroenterol 2023; 29(29): 4499-4527 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i29/4499.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i29.4499 |
