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7/10/2023 12:29:21 PM | Browse: 98 | Download: 445
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Received |
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2023-04-24 08:00 |
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Peer-Review Started |
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2023-04-24 08:00 |
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To Make the First Decision |
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Return for Revision |
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2023-05-16 02:33 |
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Revised |
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2023-05-20 03:17 |
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Second Decision |
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2023-06-02 03:11 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-06-02 08:18 |
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Articles in Press |
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2023-06-02 08:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-06-10 20:16 |
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Typeset the Manuscript |
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2023-06-24 07:04 |
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Publish the Manuscript Online |
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2023-07-10 08:58 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Raf kinase inhibitor protein combined with phosphorylated extracellular signal-regulated kinase offers valuable prognosis in gastrointestinal stromal tumor
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Zhi Qu, Luan Wang, Juan-Juan Chen and Yang Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Liaoning Province |
2020-MS-148 |
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| Corresponding Author |
Yang Wang, MD, PhD, Associate Professor, Doctor, Department of General Surgery, The 4th Affiliated Hospital of China Medical University, No.4 Chongshan Road, Huanggu District, Shenyang 110032, Liaoning Province, China. wwyy840731@126.com |
| Key Words |
Raf kinase inhibitory protein; Phosphorylated extracellular-signal-regulated kinase; Gastrointestinal stromal tumors; Immunohistochemistry; Survival analysis; Risk grade model |
| Core Tip |
Nowadays, research reports on the expression of downstream proteins of the Extracellular Signal-Regulated Kinase (ERK)/Mitogen-activated protein kinase pathway combined with Raf Kinase Inhibitor Protein (RKIP) in gastrointestinal stromal tumor (GIST) is scarce. This study will focus on this aspect and use immunohistochemistry methods, large sample survival analysis data, and the latest bioinformatics analysis techniques to answer the problem. Our experimental results showed that the expression of the two proteins had a certain negative correlation. The combined expression of RKIP and p-ERK proteins can serve as an independent risk factor for predicting the prognosis of GIST patients. Furthermore, the new risk assessment model incorporating RKIP and p-ERK has superior evaluation efficacy. |
| Publish Date |
2023-07-10 08:58 |
| Citation |
Qu WZ, Wang L, Chen JJ, Wang Y. Raf kinase inhibitor protein combined with phosphorylated extracellular signal-regulated kinase offers valuable prognosis in gastrointestinal stromal tumor. World J Gastroenterol 2023; 29(26): 4200-4213 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i26/4200.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i26.4200 |
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