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9/21/2023 9:01:36 AM | Browse: 122 | Download: 252
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Received |
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2023-04-21 15:43 |
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Peer-Review Started |
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2023-04-21 15:45 |
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To Make the First Decision |
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Return for Revision |
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2023-06-19 07:31 |
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Revised |
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2023-07-12 15:10 |
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Second Decision |
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2023-08-16 02:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-08-17 01:46 |
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Articles in Press |
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2023-08-17 01:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-09-18 01:44 |
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Publish the Manuscript Online |
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2023-09-21 08:05 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Retrospective Study |
| Article Title |
Remdesivir, dexamethasone and angiotensin-converting enzyme inhibitors use and mortality outcomes in COVID-19 patients with concomitant troponin elevation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Chukwuemeka A Umeh, Heather Maoz, Jessica Obi, Ruchi Dakoria, Smit Patel, Gargi Maity and Pranav Barve |
| Funding Agency and Grant Number |
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| Corresponding Author |
Heather Maoz, MD, Doctor, Internal Medicine, Hemet Global Medical Center, 1117 E. Devonshire Ave., Hemet, CA 92543, United States. heathermaoz@gmail.com |
| Key Words |
Coronavirus disease 2019; Troponin elevation; Remdesevir; Ace inhibitor; Steroids |
| Core Tip |
Myocarditis from direct viral injury or related to angiotensin-converting enzyme (ACE) II downregulation with subsequent hyperactivity of the renin-angiotensin-aldosterone system plays an essential role in troponin elevation in coronavirus disease 2019 (COVID-19) patients. However, the effect of antiviral medications and steroids used to treat viral myocarditis has not been well-studied in patients with elevated troponins, which this study sought to address. We found no significant difference in survival rates in COVID-19 patients with elevated troponin that received remdesivir, dexamethasone, or ACE inhibitors vs those that did not. The implication for practice is that treatment with various medications that could be beneficial in viral myocarditis did not show any mortality benefit in our study for COVID-19 patients with troponin elevation. |
| Publish Date |
2023-09-21 08:05 |
| Citation |
Umeh CA, Maoz H, Obi J, Dakoria R, Patel S, Maity G, Barve P. Remdesivir, dexamethasone and angiotensin-converting enzyme inhibitors use and mortality outcomes in COVID-19 patients with concomitant troponin elevation. World J Cardiol 2023; 15(9): 427-438 |
| URL |
https://www.wjgnet.com/1949-8462/full/v15/i9/427.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v15.i9.427 |
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