Publication Name	World Journal of Medical Genetics
Manuscript ID	85140
Country	Pakistan

Received	2023-04-13 16:12
Peer-Review Started	2023-04-13 16:15
To Make the First Decision
Return for Revision	2023-06-01 08:01
Revised	2023-06-10 07:30
Second Decision	2023-06-29 02:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-06-30 03:50
Articles in Press	2023-06-30 03:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-07-17 08:23
Publish the Manuscript Online	2023-07-20 09:52

ISSN	2220-3184 (online)
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Category	Genetics & Heredity
Manuscript Type	Opinion Review
Article Title	Role of IL-2/IL-2 receptor in pathogenesis of autoimmune disorders: Genetic and therapeutic aspects
Manuscript Source	Unsolicited Manuscript
All Author List	Sana Rafaqat and Saira Rafaqat
Funding Agency and Grant Number
Corresponding Author	Sana Rafaqat, PhD, Research Fellow, Department of Biotechnology (Specialized in Human Genetics), Lahore College for Women University, Lahore 54000, Pakistan. sana.rafaqat44@gmail.com
Key Words	IL-2; IL-2R; Pathogenesis; Autoimmune diseases; Systemic lupus erythematosus; Rheumatoid arthritis; Systemic sclerosis; Sjogren syndrome; Multiple sclerosis
Core Tip	Immune dysregulation of Interleukin-2 (IL-2) may cause tissue injury and damage leads to pathogenesis of various autoimmune diseases The aim of this review paper was to examine the role of IL-2/IL-2R in various autoimmune disorders, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), multiple sclerosis (MS) and Sjogren Syndrome (SS), which are all linked to malfunctioning of IL-2/IL-2R. IL-2 gene polymorphism is involved in increasing the risk of SLE, RA, SSc, and MS but no data has been available about the genetic role of IL-2 in the pathogenesis of Sjogren syndrome. In therapeutic approaches, a low dose of IL-2 therapy is found to be safe, effective, and well-tolerated in the treatment of SLE, RA, SSc, MS, and SS patients.
Publish Date	2023-07-20 09:52
Citation	Rafaqat S, Rafaqat S. Role of IL-2/IL-2 receptor in pathogenesis of autoimmune disorders: Genetic and therapeutic aspects. World J Med Genet 2023; 11(3): 28-38
URL	https://www.wjgnet.com/2220-3184/full/v11/i3/28.htm
DOI	https://dx.doi.org/10.5496/wjmg.v11.i3.28

Full Article (PDF)	WJMG-11-28-with-cover.pdf
Full Article (Word)	WJMG-11-28.docx
Manuscript File	85140_Auto_Edited-LJH-JLW.docx
Answering Reviewers	85140-Answering reviewers.pdf
Audio Core Tip	85140-Audio core tip.aac
Conflict-of-Interest Disclosure Form	85140-Conflict-of-interest statement.pdf
Copyright License Agreement	85140-Copyright license agreement.pdf
Peer-review Report	85140-Peer-review(s).pdf
Scientific Misconduct Check	85140-Bing-Liu JH-2.png
Scientific Misconduct Check	85140-CrossCheck.png
Scientific Editor Work List	85140-Scientific editor work list.pdf
CrossCheck Report	85140-CrossCheck report.pdf