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8/11/2023 12:08:50 PM | Browse: 117 | Download: 376
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Received |
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2023-04-20 07:31 |
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Peer-Review Started |
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2023-04-20 07:33 |
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To Make the First Decision |
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Return for Revision |
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2023-06-01 09:30 |
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Revised |
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2023-06-12 13:05 |
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Second Decision |
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2023-07-03 12:32 |
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Accepted by Journal Editor-in-Chief |
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2023-07-05 12:30 |
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Accepted by Company Editor-in-Chief |
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2023-07-07 17:05 |
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Articles in Press |
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2023-07-07 17:05 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-08-07 06:17 |
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Publish the Manuscript Online |
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2023-08-11 11:04 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Potential role of microRNA-503 in Icariin-mediated prevention of high glucose-induced endoplasmic reticulum stress
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bao-Lin Su, Liang-Liang Wang, Liang-You Zhang, Shu Zhang, Qiang Li and Gang-Yi Chen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The First Affiliated Hospital of Guangzhou University of Chinese Medicine Innovation and Strengthening Fund |
2019QN14 |
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| Corresponding Author |
Gang-Yi Chen, MD, Doctor, Department of Nephrology, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, No. 16 Jichang Road, Guangzhou 510405, Guangdong Province, China. gangyichen5001@126.com |
| Key Words |
Icariin; MicroRNA-503; Sirtuin 4; Endoplasmic reticulum stress; Diabetic nephropathy; Kidney damage |
| Core Tip |
Icariin (ICA) has shown promise as a potential therapeutic agent for diabetes mellitus (DM) by regulating the miR-503-5p/sirtuin 4 (SIRT4) axis and subsequent endoplasmic reticulum (ER) stress. This study found that ICA treatment reduced high glucose-induced inhibition of cell viability, promotion of apoptosis, and ER stress in primary rat kidney cells. Mechanistically, ICA inhibited the upregulation of miR-503-5p and subsequently restored SIRT4 levels, thereby alleviating high glucose-induced injury in cells. These findings implicate ICA as a candidate drug for the treatment of DM and miR-503-5p as a potential therapeutic target for this disease. |
| Publish Date |
2023-08-11 11:04 |
| Citation |
Su BL, Wang LL, Zhang LY, Zhang S, Li Q, Chen GY. Potential role of microRNA-503 in Icariin-mediated prevention of high glucose-induced endoplasmic reticulum stress. World J Diabetes 2023;14(8): 1234-1248 |
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i8/1234.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i8.1234 |
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