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9/15/2023 10:22:43 AM | Browse: 403 | Download: 1167
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Received |
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2023-05-24 01:02 |
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Peer-Review Started |
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2023-05-24 01:03 |
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First Decision by Editorial Office Director |
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2023-06-12 02:36 |
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2023-06-12 02:36 |
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Revised |
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2023-06-20 03:18 |
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Second Decision by Editor |
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2023-07-14 02:49 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2023-07-14 09:52 |
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Articles in Press |
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2023-07-14 09:52 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-09-08 07:43 |
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Publish the Manuscript Online |
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2023-09-15 10:15 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Clinical Neurology |
| Manuscript Type |
Basic Study |
| Article Title |
Exosomal miR-320e through wnt2targeted inhibition of the Wnt/β-catenin pathway allevisate cerebral small vessel disease and cognitive impairment
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zheng Wang, Xue-Ning Li, Shao-Nan Yang, Yuan Wang, Ke-Jin Gao, Bin Han and Ai-Jun Ma |
| Funding Agency and Grant Number |
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| Corresponding Author |
Ai-Jun Ma, MD, Attending Doctor, Department of Neurology, The Affiliated Hospital of Qingdao University, No.16, Jiangsu Street, Qingdao 266001, Shandong Province, China. drmaj@qdu.edu.cn |
| Key Words |
Exosome; Cerebral small vessel disease; miRNA-320e; Wnt2; Wnt/β-catenin pathway; Depressed |
| Core Tip |
Exosomal miR-320e is downregulated in patients with cerebral small vessel disease (CVSD), and it inhibits the Wnt/β-catenin pathway by targeting Wnt2 in response to oxidative stress. Uptake of exosomes carrying miR-320e can also target Wnt2 and inhibit the Wnt2/β-catenin pathway. Elevated miR-320e expression may protect patients with CVSD from severe cognitive impairment and depression, as it correlates positively with MoCA/EFA and HAMD/BDI scores. Therefore, exosomal miR-320e may play a protective role in CVSD progression by suppressing the Wnt/β-catenin pathway, indicating its potential as a therapeutic target for CVSD. |
| Publish Date |
2023-09-15 10:15 |
| Citation |
Wang Z, Li XN, Yang SN, Wang Y, Gao KJ, Han B, Ma AJ. Exosomal miR-320e through wnt2targeted inhibition of the Wnt/β-catenin pathway allevisate cerebral small vessel disease and cognitive impairment. World J Psychiatry 2023; 13(9): 630-644 |
| URL |
https://www.wjgnet.com/2220-3206/full/v13/i9/630.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v13.i9.630 |
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