Publication Name	World Journal of Dermatology
Manuscript ID	8540
Country	Hungary

Received	2013-12-30 10:23
Peer-Review Started	2013-12-30 11:27
To Make the First Decision	2014-02-13 16:21
Return for Revision	2014-02-20 23:47
Revised	2014-04-10 20:17
Second Decision	2014-05-29 09:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-29 09:54
Articles in Press	2014-05-29 10:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-14 16:21
Publish the Manuscript Online	2014-08-28 16:04

ISSN	2218-6190 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Dermatology
Manuscript Type	Minireviews
Article Title	What have we learned about non-involved psoriatic skin from large-scale gene expression studies?
Manuscript Source	Invited Manuscript
All Author List	Eszter Szlavicz, Kornelia Szabo, Zsuzsanna Bata-Csorgo, Lajos Kemeny and Marta Szell
Funding Agency and Grant Number	Funding Agency Grant Number OTKA NK77434 OTKA K83277 OTKA K105985 TáMOP 4.2.2.A-11/1/KONV TáMOP 4.2.2-B-10/1-2010-0012 Bolyai Foundation of the Hungarian Academy of Sciences (to Kornelia Szabo)
Corresponding Author	Eszter Szlavicz, MD, Department of Dermatology and Allergology, University of Szeged, Koranyi fasor 6, H-6720 Szeged, Hungary. szlavicz.eszter@gmail.com
Key Words	Non-involved psoriatic skin; Differential display; cDNA microarray; EDA+ fibronectin isoform; PRINS long non-coding RNA; mRNA maturation
Core Tip	Large-scale gene expression studies, including differential display and microarray, have provided valuable data on the molecular background of psoriasis pathogenesis. This review summarizes the most important results of the available literature and our large-scale gene expression studies obtained from the clinically non-involved psoriatic skin: we identified the EDA+ fibronectin splice variant as an autocrine proliferation signal for psoriatic hyperproliferative keratinocytes and PRINS, a long non-coding regulatory RNA. We believe that the characterization of new candidate genes and proteins might establish new therapeutic approaches, which may allow treatment of already existing psoriatic lesions as well as non-involved psoriatic skin by affecting molecular aberrancies, and may lead to the development of prophylactic interventions.
Publish Date	2014-08-28 16:04
Citation	Szlavicz E, Szabo K, Bata-Csorgo Zs, Kemeny L, Szell M. What have we learned about non-involved psoriatic skin from large-scale expression studies? World J Dermatol 2014; 3(3): 50-57
URL	http://www.wjgnet.com/2218-6190/full/v3/i3/50.htm
DOI	http://dx.doi.org/10.5314/wjd.v3.i3.50

Full Article (PDF)	WJD-3-50.pdf
Full Article (Word)	WJD-3-50.doc
Manuscript File	8540-Review.doc
Answering Reviewers	8540-Answering reviewers.pdf
Copyright License Agreement	8540-Copyright assignment.pdf
Peer-review Report	8540-Peer review(s).pdf
Scientific Misconduct Check	8540-CrossCheck.jpg
Scientific Editor Work List	8540-Scientific editor work list.pdf