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8/10/2023 2:29:45 PM | Browse: 275 | Download: 885
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Received |
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2023-04-26 07:48 |
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Peer-Review Started |
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2023-04-26 07:50 |
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To Make the First Decision |
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Return for Revision |
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2023-06-15 01:04 |
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Revised |
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2023-06-16 05:48 |
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Second Decision |
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2023-07-17 02:50 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-07-17 22:33 |
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Articles in Press |
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2023-07-17 22:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-07-10 15:30 |
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Typeset the Manuscript |
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2023-07-27 05:51 |
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Publish the Manuscript Online |
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2023-08-10 14:08 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Physcion increases the sensitivity of hepatocellular carcinoma to sorafenib through microRNA-370/PIM1 axis-regulated glycolysis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Ping Pan, Bu-Ren Jiya, Feng Wang and Zhu Lan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81960782 |
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| Corresponding Author |
Xiao-Ping Pan, MD, Doctor, Doctor, Department of Interventional Radiology, Inner Mongolia International Mongolian Hospital, No. 83 University East Street, Hohhot 016000, Inner Mongolia Autonomous Region, China. xiongmi7122504@163.com |
| Key Words |
Hepatocellular carcinoma; Sorafenib resistance; Physcion; Glycolysis; PIM1 |
| Core Tip |
This study investigated the effects of physcion on sorafenib-resistance of hepatocellular carcinoma (HCC) cells. Through utilizing the in vitro and in vivo model, we determined that physcion could significantly enhance the anti-tumor effects of sorafenib on sorafenib-resistant HCC cells, inducing apoptosis and suppressing cell growth. Further exploration on mechanisms identified that physcion repressing HCC cells glycolysis via targeting the microRNA-370/PIM1 axis, which consequently sensitized HCC cells to sorafenib. |
| Publish Date |
2023-08-10 14:08 |
| Citation |
Pan XP, Jiya BR, Wang F, Lan Z. Physcion increases the sensitivity of hepatocellular carcinoma to sorafenib through microRNA-370/PIM1 axis-regulated glycolysis. World J Gastrointest Oncol 2023; 15(8): 1400-1411 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i8/1400.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i8.1400 |
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