Publication Name	World Journal of Stem Cells
Manuscript ID	85452
Country	China

Received	2023-07-27 03:04
Peer-Review Started	2023-07-27 03:04
To Make the First Decision
Return for Revision	2023-08-03 22:36
Revised	2023-08-16 09:58
Second Decision	2023-09-12 02:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-09-12 20:29
Articles in Press	2023-09-12 20:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-09-18 10:47
Publish the Manuscript Online	2023-09-25 02:36

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	Mechanism of adipose-derived mesenchymal stem cell exosomes in the treatment of heart failure
Manuscript Source	Unsolicited Manuscript
All Author List	Lei Wang, Jin-Jin Zhang, Sha-Sha Wang and Liang Li
Funding Agency and Grant Number
Corresponding Author	Liang Li, MM, Doctor, Department of Geriatric Medicine, Fourth Medical Center of PLA General Hospital, No. 51 Fucheng road, Haidian District, Beijing 100048, China. liliangcc@163.com
Key Words	Adipose-derived mesenchymal stem cell exosomes; Heart failure; Cardiomyocyte apoptosis
Core Tip	Our study highlights the potential of mesenchymal stem cell exosomes (Exos) from adipose tissue as a promising therapy for heart failure (HF). Administration of adipose-derived mesenchymal stem cell Exos improved cardiac function, evidenced by increased ATP content and enhanced parameters like ejection fraction, fractional shortening, and stroke volume. Furthermore, adipose-derived stem cells (ADSCs)-Exo reduced serum levels of b-type natriuretic peptide and atrial natriuretic peptide, associated with HF progression, and exhibited anti-apoptotic effects by regulating pro- and anti-apoptotic proteins in cardiac tissue. These findings suggest that ADSCs-Exo could prevent cardiomyocyte death and inhibit HF progression.
Publish Date	2023-09-25 02:36
Citation	Wang L, Zhang JJ, Wang SS, Li L. Mechanism of adipose-derived mesenchymal stem cell exosomes in the treatment of heart failure. World J Stem Cells 2023; 15(9): 897-907
URL	https://www.wjgnet.com/1948-0210/full/v15/i9/897.htm
DOI	https://dx.doi.org/10.4252/wjsc.v15.i9.897

Full Article (PDF)	WJSC-15-897-with-cover.pdf
Full Article (Word)	WJSC-15-897.docx
The ARRIVE Guidelines	85452-The ARRIVE guidelines.pdf
Manuscript File	85452_Auto_Edited-LM.docx
Answering Reviewers	85452-Answering reviewers.pdf
Audio Core Tip	85452-Audio core tip.mp3
Biostatistics Review Certificate	85452-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	85452-Conflict-of-interest statement.pdf
Copyright License Agreement	85452-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	85452-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	85452-Language certificate.pdf
Peer-review Report	85452-Peer-review(s).pdf
Scientific Misconduct Check	85452-Bing-Wang JJ-2.png
Scientific Editor Work List	85452-Scientific editor work list.pdf