| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Observational Study |
| Article Title |
Network pharmacology and molecular docking to explore Polygoni Cuspidati Rhizoma et Radix treatment for acute lung injury
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia-Lin Zheng, Xiao Wang, Zhe Song, Peng Zhou, Gui-Ju Zhang, Juan-Juan Diao, Cheng-En Han, Guang-Yuan Jia, Xu Zhou and Bao-Qing Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shandong Province Integrated Traditional Chinese and Western Medicine Professional Disease Prevention and Control Project |
YXH2019ZXY010 |
|
| Corresponding Author |
Bao-Qing Zhang, MD, Attending Doctor, Department of Respiratory, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No. 42 Wenhua West Road, Jinan City, Jinan 250014, Shandong Province, China. mihuai8556@126.com |
| Key Words |
Traditional Chinese medicine; Acute lung injury; Infections; Database; Network pharmacology; Molecular docking |
| Core Tip |
This study used network pharmacology and molecular docking to explore the treatment of acute lung injury (ALI) using Polygoni Cuspidati Rhizoma et Radix (PCRR), a traditional Chinese medicine (TCM). Functional enrichment analysis suggested that PCRR alleviated ALI symptoms by modulating multiple pathways, including inflammation, immune modulation, and drug metabolism. We identified 13 bioactive compounds and 60 therapeutically relevant genes. Molecular docking further confirmed the strong association between the active ingredients and core targets. This study provides insights into the mechanisms of TCM at the network pharmacology level for the treatment of ALI. |
| Publish Date |
2023-06-30 12:54 |
| Citation |
Zheng JL, Wang X, Song Z, Zhou P, Zhang GJ, Diao JJ, Han CE, Jia GY, Zhou X, Zhang BQ. Network pharmacology and molecular docking to explore Polygoni Cuspidati Rhizoma et Radix treatment for acute lung injury. World J Clin Cases 2023; 11(19): 4579-4600 |
| URL |
https://www.wjgnet.com/2307-8960/full/v11/i19/4579.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v11.i19.4579 |
