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9/8/2023 9:45:24 AM | Browse: 624 | Download: 1242
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Received |
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2023-05-25 04:37 |
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2023-05-25 04:38 |
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2023-06-15 09:16 |
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2023-07-24 12:40 |
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2023-08-18 02:38 |
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2023-08-18 09:04 |
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2023-08-18 09:04 |
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Typeset the Manuscript |
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2023-08-23 07:00 |
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Publish the Manuscript Online |
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2023-09-08 09:38 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Hematology |
| Manuscript Type |
Case Report |
| Article Title |
T/myeloid mixed-phenotype acute leukemia treated with venetoclax and decitabine: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sungwoo Park, Eun Jeong Jeong, Jung Hun Kang, Gyeong-Won Lee, Se-Il Go, Dong-Hyun Lee and Eun-Ha Koh |
| Funding Agency and Grant Number |
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| Corresponding Author |
Gyeong-Won Lee, MD, PhD, Associate Professor, Division of Hematology and Oncology, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju 52727, South Korea. brightree@naver.com |
| Key Words |
Mixed-phenotype acute leukemia; Venetoclax; Decitabine; Case report |
| Core Tip |
We report a 55-year-old male diagnosed with T/myeloid mixed-phenotype acute leukemia (MPAL) who received induction chemotherapy with vincristine, prednisolone, daunorubicin, and L-asparaginase. The patient experienced septic shock 10 days post-induction therapy and received antibiotic therapy to treat extended-spectrum beta-lactamase-positive bacteremia. Bone marrow examination post-sepsis recovery revealed refractory disease. To reduce the infection risk, venetoclax and decitabine were administered as chemotherapy-free induction therapy. After two additional venetoclax/decitabine cycles, the patient underwent haploidentical peripheral blood stem-cell transplantation, subsequently achieving complete response. This is the third report documenting the successful treatment of refractory T/myeloid MPAL with venetoclax and a hypomethylating agent. |
| Publish Date |
2023-09-08 09:38 |
| Citation |
Park S, Jeong EJ, Kang JH, Lee GW, Go SI, Lee DH, Koh EH. T/myeloid mixed-phenotype acute leukemia treated with venetoclax and decitabine: A case report. World J Clin Cases 2023; 11(26): 6200-6205
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| URL |
https://www.wjgnet.com/2307-8960/full/v11/i26/6200.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v11.i26.6200 |
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