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8/25/2023 8:35:17 AM | Browse: 233 | Download: 780
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Received |
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2023-05-31 02:40 |
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Peer-Review Started |
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2023-05-31 02:42 |
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To Make the First Decision |
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Return for Revision |
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2023-07-08 09:26 |
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Revised |
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2023-07-15 03:05 |
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Second Decision |
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2023-07-31 02:56 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-07-31 19:12 |
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Articles in Press |
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2023-07-31 19:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-08-22 00:17 |
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Publish the Manuscript Online |
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2023-08-25 07:09 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Basic Study |
| Article Title |
Linolenic acid-metronidazole inhibits the growth of Helicobacter pylori through oxidation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Ting Zhou, Yuan-Yuan Dai, Li-Juan Liao, Shi-Xian Yang, Hao Chen, Juan-Li Zhao, Yan-Qiang Huang and Liang Huang |
| Funding Agency and Grant Number |
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| Corresponding Author |
Liang Huang, MD, Doctor, Doctor, Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting, Youjiang Medical University for Nationalities, No. 98 Chengxiang Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. youyihuangl@163.com |
| Key Words |
Helicobacter pylori; Oxidation; Superoxide dismutase; SodB genes; MdaB genes |
| Core Tip |
The clarithromycin resistant Helicobacter pylori (H. pylori) is listed by the World Health Organization as the priority bacteria in urgent need of developing new antibiotics. Our previous research found that linolenic acid-metronidazole has a good antibacterial effect on H. pylori and is not easy to develop drug resistance. Therefore, we further explored its antibacterial mechanism against H. pylori. It was found that it mainly kills H. pylori by inducing oxidative stress, DNA damage, phosphatidylserine ectropionation, and changes on cell morphology. This study may provide a theoretical basis for the development and application of new anti H. pylori lead compound. |
| Publish Date |
2023-08-25 07:09 |
| Citation |
Zhou WT, Dai YY, Liao LJ, Yang XS, Chen H, Zhao JL, Huang YQ, Huang L. Linolenic acid-metronidazole inhibits the growth of Helicobacter pylori through oxidation. World J Gastroenterol 2023; 29(32): 4860-4872 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i32/4860.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i32.4860 |
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