Publication Name	World Journal of Critical Care Medicine
Manuscript ID	85707
Country	India

Received	2023-05-11 11:25
Peer-Review Started	2023-05-11 11:27
First Decision by Editorial Office Director	2023-06-15 09:31
Return for Revision	2023-06-15 09:31
Revised	2023-06-24 06:39
Publication Fee Transferred
Second Decision by Editor	2023-07-05 02:51
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2023-07-06 02:32
Articles in Press	2023-07-06 02:32
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-09-01 01:57
Publish the Manuscript Online	2023-09-05 06:48

ISSN	2220-3141(online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Critical Care Medicine
Manuscript Type	Retrospective Study
Article Title	Delayed inflammatory pulmonary syndrome: A distinct clinical entity in the spectrum of inflammatory syndromes in COVID-19 infection?
Manuscript Source	Invited Manuscript
All Author List	Prithviraj Bose, Binila Chacko, Ashwin Oliver Arul, Leena Robinson Vimala, Balamugesh Thangakunam, George M Varghese, Mohan Jambugulam, Audrin Lenin and John Victor Peter
Funding Agency and Grant Number
Corresponding Author	John Victor Peter, Visiting Professor, FRACP, MAMS, MD, Professor, Department of Medical Intensive Care, Christian Medical College, Vellore 632004, Tamil Nadu, India. peterjohnvictor@yahoo.com.au
Key Words	COVID-19; ARDS; Multisystem Inflammatory Syndrome in Adults; Long COVID; Organizing pneumonia
Core Tip	Delayed respiratory deterioration in critically ill coronavirus disease 2019 (COVID-19) in the absence of new infection, fluid overload, pneumothorax, or lung collapse is seen in a subset of patients admitted to the intensive care unit. This presentation does not fit in to the definition of Multisystem Inflammatory Syndrome Adults, owing to the predominance of pulmonary symptoms and the notable absence of cardiac, gastrointestinal, and mucocutaneous manifestations. In the current study, five patients developed worsening respiratory function requiring escalation of ventilatory support after the third week of COVID-19 illness. This was accompanied by elevated inflammatory markers. All five patients showed clinical response to immunomodulation. This delayed inflammatory pulmonary syndrome contrasts Multisystem Inflammatory Syndrome Adults where extrapulmonary organ involvement predominates.
Publish Date	2023-09-05 06:48
Citation	Bose P, Chacko B, Arul AO, Robinson Vimala L, Thangakunam B, Varghese GM, Jambugulam M, Lenin A, Peter JV. Delayed inflammatory pulmonary syndrome: A distinct clinical entity in the spectrum of inflammatory syndromes in COVID-19 infection? World J Crit Care Med 2023; 12(4): 226-235
URL	https://www.wjgnet.com/2220-3141/full/v12/i4/226.htm
DOI	https://dx.doi.org/10.5492/wjccm.v12.i4.226

Full Article (PDF)	WJCCM-12-226-with-cover.pdf
Full Article (Word)	WJCCM-12-226.docx