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8/17/2023 7:19:22 AM | Browse: 107 | Download: 448
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Received |
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2023-05-17 02:31 |
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Peer-Review Started |
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2023-05-17 02:33 |
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2023-07-04 08:38 |
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2023-07-05 16:04 |
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Second Decision |
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2023-07-26 02:55 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-07-27 00:42 |
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Articles in Press |
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2023-07-27 00:42 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-08-14 06:49 |
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Publish the Manuscript Online |
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2023-08-17 07:08 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Basic Study |
| Article Title |
Pilot study of genome-wide DNA methylation and gene expression for treatment response to escitalopram in panic disorder
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi-Li Zou, Yuan Zhang, Yu-Lan Huang, Jin-Yu Wang, Bo Zhou and Hua-Fu Chen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Sichuan Provincial People’s Hospital Translational Medicine Fund |
2021LY02 |
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| Corresponding Author |
Hua-Fu Chen, PhD, Professor, Department of Psychosomatic Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, No. 32, West Second Section First Ring Road, Chengdu 611731, Sichuan Province, China. chenhf@uestc.edu.cn |
| Key Words |
Panic disorder; Methylation; Expression profiling; Escitalopram |
| Core Tip |
No genome-wide methylation studies or mRNA sequencing have been conducted to identify early response biomarkers in patients with panic disorder (PD). This study aimed to compare genome-wide methylation and gene expression patterns between responsive and non-responsive patients with PD after 4 wk of escitalopram treatment. A total of 701 differentially methylated positions (DMPs) were found between responders and non-responders, and the hyper- and hypomethylated CpG sites were 511 (72.9%) and 190 (27.1%), respectively. This preliminary study showed that DMPs might be associated with the treatment response to escitalopram in PD. |
| Publish Date |
2023-08-17 07:08 |
| Citation |
Zou ZL, Zhang Y, Huang YL, Wang JY, Zhou B, Chen HF. Pilot study of genome-wide DNA methylation and gene expression for treatment response to escitalopram in panic disorder. World J Psychiatry 2023; 13(8): 524-532 |
| URL |
https://www.wjgnet.com/2220-3206/full/v13/i8/524.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v13.i8.524 |
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