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11/15/2023 3:50:16 PM | Browse: 43 | Download: 65
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 85901
Country/Territory United States
2023-05-21 18:07
Peer-Review Started
2023-05-21 21:46
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Return for Revision
2023-08-15 18:17
2023-09-14 03:32
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2023-10-16 08:57
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2023-10-23 06:56
Articles in Press
2023-10-23 06:56
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Typeset the Manuscript
2023-11-03 08:20
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2023-11-15 13:46
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Retrospective Study
Article Title Baseline neutrophil-lymphocyte ratio and platelet-lymphocyte ratio appear predictive of immune treatment related toxicity in hepatocellular carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Sirish Dharmapuri, Umut Özbek, Hiren Jethra, Tomi Jun, Thomas U Marron, Anwaar Saeed, Yi-Hsiang Huang, Mahvish Muzaffar, Matthias Pinter, Lorenz Balcar, Claudia Fulgenzi, Suneetha Amara, Arndt Weinmann, Nicola Personeni, Bernhard Scheiner, Tiziana Pressiani, Musharraf Navaid, Bertram Bengsch, Sonal Paul, Uqba Khan, Dominik Bettinger, Naoshi Nishida, Yehia Ibrahim Mohamed, Arndt Vogel, Anuhya Gampa, James Korolewicz, Antonella Cammarota, Ahmed Kaseb, Peter R. Galle, Anjana Pillai, Yinghong Wang, Alessio Cortellini, Masatoshi Kudo, Antonio D'Alessio, Lorenza Rimassa, David James Pinato and Celina Ang
Funding Agency and Grant Number
Corresponding Author Sirish Dharmapuri, MD, Assistant Professor, Tisch Cancer Institute , Icahn school of Medicine at Mount Sinai, No. 425 West 59th Street, New York, NY 10029, United States. sirish.dharmapuri@gmail.com
Key Words Neutrophil-lymphocyte ratio; Platelet-lymphocyte ratio; Inflammatory biomarkers; Immunotherapy; Immune toxicity
Core Tip In this study of hepatocellular carcinoma (HCC) patients treated with immune checkpoint inhibitors (ICI), the association between two biomarkers, neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), and immune-related adverse events (IrAEs) was examined. Data from 361 patients showed that a higher PLR (> 300) was significantly associated with a lower incidence of grade ≥ 2 IrAEs. A trend was observed between a higher NLR (> 5) and lower incidence of grade ≥ 2 IrAEs. Multivariate analyses confirmed PLR as an independent predictive marker for grade ≥ 2 IrAEs. These findings suggest that NLR and PLR could be potential predictive markers for IrAEs in HCC patients receiving ICI treatment.
Publish Date 2023-11-15 13:46
Citation Dharmapuri S, Özbek U, Jethra H, Jun T, Marron TU, Saeed A, Huang YH, Muzaffar M, Pinter M, Balcar L, Fulgenzi C, Amara S, Weinmann A, Personeni N, Scheiner B, Pressiani T, Navaid M, Bengsch B, Paul S, Khan U, Bettinger D, Nishida N, Mohamed YI, Vogel A, Gampa A, Korolewicz J, Cammarota A, Kaseb A, Galle PR, Pillai A, Wang YH, Cortellini A, Kudo M, D’Alessio A, Rimassa L, Pinato DJ, Ang C. Baseline neutrophil-lymphocyte ratio and platelet-lymphocyte ratio appear predictive of immune treatment related toxicity in hepatocellular carcinoma. World J Gastrointest Oncol 2023; 15(11): 1900-1912
URL https://www.wjgnet.com/1948-5204/full/v15/i11/1900.htm
DOI https://dx.doi.org/10.4251/wjgo.v15.i11.1900
Full Article (PDF) WJGO-15-1900-with-cover.pdf
Full Article (Word) WJGO-15-1900.docx
Manuscript File 85901_Auto_Edited-JLW.docx
Answering Reviewers 85901-Answering reviewers.pdf
Audio Core Tip 85901-Audio core tip.mp3
Biostatistics Review Certificate 85901-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 85901-Conflict-of-interest statement.pdf
Copyright License Agreement 85901-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 85901-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 85901-Institutional review board statement.pdf
Peer-review Report 85901-Peer-review(s).pdf
Scientific Misconduct Check 85901-Bing-Qu XL-2.jpg
Scientific Editor Work List 85901-Scientific editor work list.pdf