Publication Name	World Journal of Clinical Cases
Manuscript ID	85906
Country	Mexico

Received	2023-05-22 00:49
Peer-Review Started	2023-05-22 00:49
To Make the First Decision
Return for Revision	2023-07-03 08:30
Revised	2023-07-17 00:31
Second Decision	2023-08-08 02:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-08-08 07:13
Articles in Press	2023-08-08 07:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-08-14 08:17
Publish the Manuscript Online	2023-08-25 08:26

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Toxicology
Manuscript Type	Minireviews
Article Title	Effect of pesticides on phosphorylation of tau protein, and its influence on Alzheimer’s disease
Manuscript Source	Unsolicited Manuscript
All Author List	Erandis D Torres-Sánchez, Genaro G Ortiz, Emmanuel Reyes-Uribe, Juan H Torres-Jasso and Joel Salazar-Flores
Funding Agency and Grant Number
Corresponding Author	Joel Salazar-Flores, PhD, N/A, Department of Medical and Life Sciences, University Center of la Cienega, University of Guadalajara, Linda Vista 1115, Ocotlan 47820, Jalisco, Mexico. joel.salazar@academicos.udg.mx
Key Words	Organochlorines; Organophosphates; Carbamates; Pyrethroids; Neonicotinoids; Tau protein
Core Tip	Exposure to pesticides occurs frequently through contact with contaminated particles, food, or water. In 2022, the Alzheimer’s Association emphasized that contact with these pollutants is a risk factor for Alzheimer diseases. This study showed that contact with organochlorines, organophosphates, carbamates, pyrethroids and neonicotinoids modified mechanisms related to tau hyperphosphorylation and neuroinflammation. In cognitive findings, these chemicals altered memory, attention, and problem-solving processes. Few published studies have evaluated the effect of these pesticides on tau protein. Therefore, this review is novel in the sense that it presents an analysis for each pesticide class.
Publish Date	2023-08-25 08:26
Citation	Torres-Sánchez ED, Ortiz GG, Reyes-Uribe E, Torres-Jasso JH, Salazar-Flores J. Effect of pesticides on phosphorylation of tau protein, and its influence on Alzheimer’s disease. World J Clin Cases 2023; 11(24): 5628-5642
URL	https://www.wjgnet.com/2307-8960/full/v11/i24/5628.htm
DOI	https://dx.doi.org/10.12998/wjcc.v11.i24.5628

Full Article (PDF)	WJCC-11-5628-with-cover.pdf
Full Article (Word)	WJCC-11-5628.docx
Manuscript File	85906_Auto_Edited-JLW.docx
Answering Reviewers	85906-Answering reviewers.pdf
Audio Core Tip	85906-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	85906-Conflict-of-interest statement.pdf
Copyright License Agreement	85906-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	85906-Language certificate.pdf
Peer-review Report	85906-Peer-review(s).pdf
Scientific Misconduct Check	85906-Bing-Wang JJ-2.png
Scientific Editor Work List	85906-Scientific editor work list.pdf