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9/25/2023 4:42:09 AM | Browse: 168 | Download: 432
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Received |
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2023-05-31 10:59 |
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Peer-Review Started |
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2023-05-31 11:01 |
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To Make the First Decision |
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Return for Revision |
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2023-06-14 18:16 |
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Revised |
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2023-06-22 00:08 |
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Second Decision |
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2023-08-22 03:01 |
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Accepted by Journal Editor-in-Chief |
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2023-08-22 13:56 |
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Accepted by Company Editor-in-Chief |
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2023-08-23 08:26 |
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Articles in Press |
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2023-08-23 08:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-09-18 10:48 |
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Publish the Manuscript Online |
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2023-09-25 02:36 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Integrin beta 3-overexpressing mesenchymal stromal cells display enhanced homing and can reduce atherosclerotic plaque
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hai-Juan Hu, Xue-Ru Xiao, Tong Li, De-Min Liu, Xue Geng, Mei Han and Wei Cui |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82100301 |
| Key Science and Technology Research Program of Hebei Provincial Department of Health |
20221014 |
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| Corresponding Author |
Wei Cui, PhD, Professor, First Division, Department of Cardiology, The Second Hospital of Hebei Medical University and Institute of Cardiocerebrovascular Disease of Hebei Province, No. 215 Heping West Road, Shijiazhuang 050000, Hebei Province, China. cuiweihb2h@163.com |
| Key Words |
Atherosclerosis; Inflammation; Integrin beta 3; Mesenchymal stem cells; Arg-Gly-Asp structure; Umbilical cord |
| Core Tip |
Mesenchymal stem cell (MSC) transplantation is considered a new treatment for atherosclerosis. However, research regarding homing of MSCs to atherosclerotic lesions is insufficient. Here, we transplanted integrin beta 3 (ITGB3)-overexpressing MSCs into a mouse model of atherosclerosis. ITGB3-overexpressing MSCs were more greatly accumulated in atherosclerotic plaques. These MSCs prevented plaque progression by shifting the local cytokine profile. The use of ITGB3-overexpressing MSCs may be a novel tool to treat atherosclerosis. |
| Publish Date |
2023-09-25 02:36 |
| Citation |
Hu HJ, Xiao XR, Li T, Liu DM, Geng X, Han M, Cui W. Integrin beta 3-overexpressing mesenchymal stromal cells display enhanced homing and can reduce atherosclerotic plaque. World J Stem Cells 2023; 15(9): 931-946 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i9/931.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i9.931 |
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