Publication Name	World Journal of Diabetes
Manuscript ID	86242
Country	China

Received	2023-07-06 08:56
Peer-Review Started	2023-07-06 08:56
To Make the First Decision
Return for Revision	2023-07-27 08:32
Revised	2023-08-02 03:40
Second Decision	2023-08-07 03:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-08-15 06:15
Articles in Press	2023-08-15 06:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-09-19 02:00
Publish the Manuscript Online	2023-10-09 11:18

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Obstetrics & Gynecology
Manuscript Type	Retrospective Study
Article Title	Effects of insulin aspart and metformin on gestational diabetes mellitus and inflammatory markers
Manuscript Source	Unsolicited Manuscript
All Author List	Yan Wang, Min Song and Bang-Ruo Qi
Funding Agency and Grant Number
Corresponding Author	Bang-Ruo Qi, MD, Lecturer, Department of Obstetrics and Gynecology, Sanya Women and Children’s Hospital Managed by Shanghai Children’s Medical Center, No. 339 Yingbin Road, Jiyang District, Sanya 572099, Hainan Province, China. bangruoqi@126.com
Key Words	Insulin aspart; Metformin; Gestational diabetes mellitus; Efficacy; Homocysteine; Tumor necrosis factor-α; Interleukin-6; C-reactive protein
Core Tip	This study investigated the clinical effect of insulin aspart combined with metformin on gestational diabetes mellitus and serum homocysteine (Hcy), tumor necrosis factor-α, interleukin-6 and C-reactive protein, which represents a novel aspect in the field. The combination of drugs significantly improved the condition of patients, reduced adverse pregnancy outcomes and incidence of adverse reactions, decreased blood-glucose-related indicators, Hcy, and serum inflammatory cytokine levels, and exhibited a high level of safety. These findings provide an important basis for the clinical application and popularization of this combination therapy.
Publish Date	2023-10-09 11:18
Citation	Wang Y, Song M, Qi BR. Effects of insulin aspart and metformin on gestational diabetes mellitus and inflammatory markers. World J Diabetes 2023; 14(10): 1532-1540
URL	https://www.wjgnet.com/1948-9358/full/v14/i10/1532.htm
DOI	https://dx.doi.org/10.4239/wjd.v14.i10.1532

Full Article (PDF)	WJD-14-1532-with-cover.pdf
Full Article (Word)	WJD-14-1532.docx
Manuscript File	86242_Auto_Edited-JLW.docx
Answering Reviewers	86242-Answering reviewers.pdf
Audio Core Tip	86242-Audio core tip.m4a
Biostatistics Review Certificate	86242-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	86242-Conflict-of-interest statement.pdf
Copyright License Agreement	86242-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	86242-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	86242-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	86242-Language certificate.pdf
Peer-review Report	86242-Peer-review(s).pdf
Scientific Misconduct Check	86242-Bing-Wang JJ-2.png
Scientific Editor Work List	86242-Scientific editor work list.pdf
CrossCheck Report	86242-CrossCheck report.pdf