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9/25/2023 9:36:53 AM | Browse: 275 | Download: 842
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Received |
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2023-06-15 06:59 |
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Peer-Review Started |
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2023-06-15 07:02 |
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To Make the First Decision |
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Return for Revision |
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2023-08-26 16:53 |
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Revised |
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2023-09-08 14:58 |
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Second Decision |
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2023-09-14 02:53 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-09-14 08:32 |
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Articles in Press |
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2023-09-14 08:32 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-09-19 05:39 |
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Publish the Manuscript Online |
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2023-09-25 09:07 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Leukocyte immunoglobulin-like receptor B2 overexpression as a promising therapeutic target and noninvasive screening biomarker for colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qian-Qian Wang, Lei Zhou, Geng Qin, Chang Tan, Yuan-Chen Zhou and Shu-Kun Yao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Development Plan for Precision Medicine Research |
2017YFC0910002 |
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| Corresponding Author |
Shu-Kun Yao, MD, PhD, Professor, Department of Gastroenterology, Peking University China-Japan Friendship School of Clinical Medicine, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com |
| Key Words |
Colorectal cancer; Leukocyte immunoglobulin-like receptor B2; Angiopoietin-like protein 2; Therapeutic target; Noninvasive screening biomarker |
| Core Tip |
Based on prior proteomic research rather than simple data mining, this study innovatively proposed and validated that leukocyte immunoglobulin-like receptor B2 (LILRB2) and its ligand, the angiopoietin-like protein 2 protein, are significantly overexpressed in colorectal cancer (CRC) and closely associated with tumour progression and a poor prognosis. In addition, this study is the first to propose that serum LILRB2 concentration can be used as a novel screening biomarker with a sensitivity of 89.74%, a specificity of 88.89% and an accuracy rate of 89.63% for the diagnosis of CRC. The sensitivity and accuracy were significantly higher than those of carcinoembryonic antigen and carbohydrate antigen 19-9. Therefore, LILRB2 could be a promising therapeutic target and noninvasive screening biomarker for CRC. |
| Publish Date |
2023-09-25 09:07 |
| Citation |
Wang QQ, Zhou L, Qin G, Tan C, Zhou YC, Yao SK. Leukocyte immunoglobulin-like receptor B2 overexpression as a promising therapeutic target and noninvasive screening biomarker for colorectal cancer. World J Gastroenterol 2023; 29(37): 5313-5326 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i37/5313.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i37.5313 |
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