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9/14/2023 3:00:54 PM | Browse: 247 | Download: 622
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Received |
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2023-06-25 05:57 |
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Peer-Review Started |
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2023-06-25 05:59 |
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To Make the First Decision |
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Return for Revision |
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2023-08-08 04:44 |
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Revised |
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2023-08-10 06:55 |
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Second Decision |
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2023-08-25 02:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-08-25 07:40 |
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Articles in Press |
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2023-08-25 07:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-09-06 08:05 |
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Publish the Manuscript Online |
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2023-09-14 14:58 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Regenerating gene 4 promotes chemoresistance of colorectal cancer by affecting lipid droplet synthesis and assembly
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cong-Yu Zhang, Rui Zhang, Li Zhang, Zi-Mo Wang, Hong-Zhi Sun, Zheng-Guo Cui and Hua-Chuan Zheng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Scientific Foundation of China |
No. 81672700 |
| Natural Science Foundation of Hebei Province |
No. 21377772D; No. H2022406034 |
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| Corresponding Author |
Hua-Chuan Zheng, MD, PhD, Professor, Cancer Center, The First Affiliated Hospital of Jinzhou Medical University, No. 2 Fifth Duan, Renmin Street, Guta District, Jinzhou 121001 , Liaoning Province, China. zheng_huachuan@hotmail.com |
| Key Words |
Colorectal cancer; Regenerating gene 4; Aggressive behavior; Prognosis; Chemoresistance; Lipid droplet formation; Epidermal growth factor receptor signa |
| Core Tip |
The roles of regenerating gene 4 (REG4) in colorectal cancer (CRC) and the related molecular mechanisms are still unknown. REG4 may be involved in tumorigenesis and aggressiveness of CRC via the epidermal growth factor receptor-phosphoinositide 3-kinase-Akt-nuclear factor-κB pathway, and chemoresistance through lipid droplet assembly. REG4 might be used as a useful marker for colorectal carcinogenesis and subsequent progression, as well as a potential gene therapy target. |
| Publish Date |
2023-09-14 14:58 |
| Citation |
Zhang CY, Zhang R, Zhang L, Wang ZM, Sun HZ, Cui ZG, Zheng HC. Regenerating gene 4 promotes chemoresistance of colorectal cancer by affecting lipid droplet synthesis and assembly. World J Gastroenterol 2023; 29(35): 5104-5124 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i35/5104.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i35.5104 |
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