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9/14/2023 3:00:54 PM | Browse: 130 | Download: 267
Publication Name World Journal of Gastroenterology
Manuscript ID 86548
Country China
Received
2023-06-25 05:57
Peer-Review Started
2023-06-25 05:59
To Make the First Decision
Return for Revision
2023-08-08 04:44
Revised
2023-08-10 06:55
Second Decision
2023-08-25 02:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-08-25 07:40
Articles in Press
2023-08-25 07:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-09-06 08:05
Publish the Manuscript Online
2023-09-14 14:58
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Regenerating gene 4 promotes chemoresistance of colorectal cancer by affecting lipid droplet synthesis and assembly
Manuscript Source Unsolicited Manuscript
All Author List Cong-Yu Zhang, Rui Zhang, Li Zhang, Zi-Mo Wang, Hong-Zhi Sun, Zheng-Guo Cui and Hua-Chuan Zheng
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Scientific Foundation of China No. 81672700
Natural Science Foundation of Hebei Province No. 21377772D; No. H2022406034
Corresponding Author Hua-Chuan Zheng, MD, PhD, Professor, Cancer Center, The First Affiliated Hospital of Jinzhou Medical University, No. 2 Fifth Duan, Renmin Street, Guta District, Jinzhou 121001 , Liaoning Province, China. zheng_huachuan@hotmail.com
Key Words Colorectal cancer; Regenerating gene 4; Aggressive behavior; Prognosis; Chemoresistance; Lipid droplet formation; Epidermal growth factor receptor signa
Core Tip The roles of regenerating gene 4 (REG4) in colorectal cancer (CRC) and the related molecular mechanisms are still unknown. REG4 may be involved in tumorigenesis and aggressiveness of CRC via the epidermal growth factor receptor-phosphoinositide 3-kinase-Akt-nuclear factor-κB pathway, and chemoresistance through lipid droplet assembly. REG4 might be used as a useful marker for colorectal carcinogenesis and subsequent progression, as well as a potential gene therapy target.
Publish Date 2023-09-14 14:58
Citation Zhang CY, Zhang R, Zhang L, Wang ZM, Sun HZ, Cui ZG, Zheng HC. Regenerating gene 4 promotes chemoresistance of colorectal cancer by affecting lipid droplet synthesis and assembly. World J Gastroenterol 2023; 29(35): 5104-5124
URL https://www.wjgnet.com/1007-9327/full/v29/i35/5104.htm
DOI https://dx.doi.org/10.3748/wjg.v29.i35.5104
Full Article (PDF) WJG-29-5104-with-cover.pdf
Full Article (Word) WJG-29-5104.docx
Manuscript File 86548_Auto_Edited-JLW.docx
Answering Reviewers 86548-Answering reviewers.pdf
Audio Core Tip 86548-Audio core tip.mp3
Biostatistics Review Certificate 86548-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 86548-Conflict-of-interest statement.pdf
Copyright License Agreement 86548-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 86548-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 86548-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 86548-Language certificate.pdf
Supplementary Material 86548-Supplementary material.pdf
Peer-review Report 86548-Peer-review(s).pdf
Scientific Misconduct Check 86548-Bing-Qu XL-2.png
Scientific Editor Work List 86548-Scientific editor work list.pdf
CrossCheck Report 86548-CrossCheck report.pdf